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Daily intake of pht...
Daily intake of phthalates, MEHP, and DINCH by ingestion and inhalation
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- Weiss, Jana M. (författare)
- Sveriges lantbruksuniversitet,Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Swedish University of Agricultural Sciences, Sweden,Institutionen för vatten och miljö,Department of Aquatic Sciences and Assessment,Stockholm University
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- Gustafsson, Åsa (författare)
- Umeå universitet,Kemiska institutionen,Swetox, Karolinska Institute, Unit of Toxicology Sciences, Forskargatan 20, 151 36, Södertälje, Sweden
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- Gerde, Per (författare)
- Karolinska Institutet
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Bergman, Åke (författare)
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- Lindh, Christian H (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Krais, Annette M (författare)
- Karolinska Institute,Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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(creator_code:org_t)
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- Elsevier, 2018
- 2018
- Engelska.
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Ingår i: Chemosphere. - : Elsevier. - 0045-6535 .- 1879-1298. ; 208, s. 40-49
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Phthalate esters, suspected endocrine disrupting chemicals, are used in a wide range of applications. Because phthalate esters are not covalently bound, they can easily leach into the indoor environment and associate to dust particles. Thus, exposure may occur through inhalation, ingestion, or contact with the skin. However, it is unclear to what degree indoor dust contributes to the daily intake of phthalate esters.This study investigates household dust as an exposure pathway for seven phthalate esters, the monoester MEHP, and the plasticizer DINCH. Household dust collected from children's sleeping rooms and from living rooms were analysed using gas and liquid chromatography tandem mass spectrometry. To compare two exposure pathways, different dust particle sizes were generated: a respirable fraction (<5 mu m) and an ingested particle fraction in the anticipated size range of skin adherence (<75 mu m). Modelling of dust inhalation and ingestion showed that the daily intake of dust-bound phthalate esters was likely to be 2 times (inhalation) to 12 times (ingestion) higher for 21-month-old children than for adults. These children's daily uptake of phthalate esters was 40-140 times higher through ingestion than inhalation. Furthermore, dust may be an exposure pathway for phthalate esters as well as for MEHP. Therefore, phthalate monoesters could be environmental contaminants of their own and need to be considered in health risk assessments. (C) 2018 Elsevier Ltd. All rights reserved.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
Nyckelord
- Phthalate esters
- Phthalate monoesters
- Household dust
- Pollution particles
- Indoor pollution
- Indoor environment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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