Elevated serum high-sensitivity cardiac troponin I is related to mortality in COPD

• Background: Cardiovascular diseases are the most common comorbid condition among subjects with COPD, but the predictive value of high-sensitivity cardiac troponin I (hs-cTnI) on prognosis has rarely been studied in population surveys.Aim: To assess the prevalence and impact of elevated serum hs-cTnI on mortality among subjects with COPD and normal lung function (NLF).Methods: In 2002-04, subjects with FEV1/VC <0.70 (COPD, n=993) and age- and sex-matched referents without COPD were identified from population-based cohorts. In 2005, structured interview, post-bronchodilator spirometry and blood sampling were performed in individuals with COPD (n=601) and referents (n=954), where 755 referents had NLF. Hs-cTnI was analysed in serum and values ≥5 ng/L were defined as elevated. Mortality data were collected until 2010.Results: The prevalence of elevated hs-cTnI was higher among COPD compared to NLF (31.1% vs. 24.9%, p=0.01). The 5-year cumulative mortality in individuals with elevated hs-cTnI was higher in COPD than in NLF (29.9% vs. 14.9%; p<0.001). In a cox-regression model adjusting for age, sex, pack-years and self-reported ischemic heart disease, elevated hs-cTnI was associated with an increased risk for death in COPD (HR 2.64, 95%CI 1.55-4.51), but not in those with NLF (HR 1.18, 95%CI 0.66-2.10). The increased risk in COPD remained after adjusting for disease severity.Conclusion: In this population-based study, elevated serum hs-cTnI concentrations were associated with increased risk for death among individuals with COPD, but not in those with NLF during a 5-year follow-up.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Publikations- och innehållstyp

vet (ämneskategori)

art (ämneskategori)