Sökning: id:"swepub:oai:DiVA.org:umu-158485" >
Mapping of Human Pa...
Mapping of Human Papilloma Virus, p16, and Epstein-Barr Virusin Non-Malignant Tonsillar Disease
-
- Holm, Anna (författare)
- Umeå universitet,Öron- näs- och halssjukdomar,Östersunds Hosp, Div Otorhinolaryngol, Dept Clin Sci, Östersund, Sweden
-
- Schindele, Alexandra (författare)
- Umeå universitet,Öron- näs- och halssjukdomar,Östersunds hospital, Sweden,Östersunds Hosp, Div Otorhinolaryngol, Dept Clin Sci, Östersund, Sweden;Jämtland Hadedalen Cty Council, Östersund, Sweden
-
- Allard, Annika (författare)
- Umeå universitet,Avdelningen för virologi,Östersunds Hosp, Div Clin Virol, Dept Clin Microbiol, Östersund, Sweden
-
visa fler...
-
- Eriksson, Irene (författare)
- Umeå universitet,Avdelningen för virologi,Östersunds Hosp, Div Clin Virol, Dept Clin Microbiol, Östersund, Sweden
-
- Sandström, Karl, 1973- (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
-
- Laurell, Göran (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
-
- Nylander, Karin (författare)
- Umeå universitet,Patologi,Östersunds Hosp, Div Pathol, Dept Ear Nose & Throat, Östersund, Sweden
-
- Olofsson, Katarina (författare)
- Umeå universitet,Öron- näs- och halssjukdomar,Östersunds Hosp, Div Otorhinolaryngol, Dept Clin Sci, Östersund, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2019-04-12
- 2019
- Engelska.
-
Ingår i: Laryngoscope Investigative Otolaryngology (LIO). - : Wiley-Blackwell. - 2378-8038. ; 4:3, s. 285-291
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://onlinelibrar...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objectives: Due to their location in the entrance of the aero‐digestive tract, tonsils are steadily exposed to viruses. Human papilloma virus (HPV) and Epstein‐Barr virus (EBV) are two potentially oncogenic viruses that tonsils encounter. The incidence of HPV positive tonsillar cancer is on the rise and it is unknown when infection with HPV occurs.Aim: To investigate if tonsils are infected with HPV and EBV, to study the co‐expression of HPV and its surrogate marker p16, and to evaluate the number of EBV positive cells in benign tonsillar disease.Materials and Methods: Tonsils from 40 patients in a university hospital were removed due to hypertrophy, chronic or recurrent infection. These were analyzed for presence of HPV, its surrogate marker p16, and EBV. HPV was studied using PapilloCheck (a PCR method), while p16 was identified in epithelial and lymphoid tissue with immunohistochemistry and EBV using EBER‐ISH (Epstein‐Barr encoding region–in situ hybridization).Results: HPV was not detected, and p16 was present at low numbers in all epithelial samples as well as in 92.5% of the lymphoid tonsillar samples. At least one EBER‐positive cell was seen in 65% of cases. Larger numbers of EBER‐expressing cells were only seen in two cases.Conclusion: These findings demonstrate that EBV and HPV infect tonsils independently, but further studies are warranted to confirm their infectious relationship.Level of Evidence: Cross‐sectional study
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Human papillomavirus
- Epstein-Barr virus
- non-malignant tonsillar disease
- EBER-ISH
- PapilloCheck
- immunohistochemistry
- oto-rhino-laryngologi
- Oto-Rhino-Laryngology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas