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Chlorinated persist...
Chlorinated persistent organic pollutants and type 2 diabetes - A population-based study with pre- and post- diagnostic plasma samples
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- Tornevi, Andreas (författare)
- Umeå University,Umeå universitet,Avdelningen för hållbar hälsa
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- Sommar, Johan (författare)
- Umeå University,Umeå universitet,Avdelningen för hållbar hälsa
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- Rantakokko, Panu (författare)
- Finnish National Institute for Health and Welfare
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- Bergdahl, Ingvar A. (författare)
- Umeå University,Karolinska Institute,Karolinska Institutet
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- Donat-Vargas, Carolina (författare)
- Karolinska Institute,Karolinska Institutet
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- Kiviranta, Hannu (författare)
- Finnish National Institute for Health and Welfare
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- Rolandsson, Olov (författare)
- Umeå University,Umeå universitet,Allmänmedicin
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- Rylander, Lars (författare)
- Lund University,Lunds universitet,Miljöepidemiologi,Forskargrupper vid Lunds universitet,Environmental Epidemiology,Lund University Research Groups
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- Wennberg, Maria, 1974- (författare)
- Umeå University,Umeå universitet,Avdelningen för hållbar hälsa
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- Bergdahl, Ingvar A. (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- Engelska.
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Ingår i: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 174, s. 35-45
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Persistent organic pollutants (POPs) have been associated with type 2 diabetes (T2D), but causality is uncertain.OBJECTIVE: Within longitudinal population-based data from northern Sweden, we assessed how POPs associated with T2D prospectively and cross-sectionally, and further investigated factors related to individual changes in POP concentrations.METHODS: For 129 case-controls pairs matched by age, sex and date of sampling, plasma concentrations of hexachlorobenzene (HCB), dichlorodiphenyl-dichloroethylene (p,p'-DDE), dioxin-like (DL) polychlorinated biphenyl congeners (PCB-118 and PCB-156), and non-dioxin like (NDL-PCB: PCB-74, -99, -138 -153, -170, -180, -183 and PCB-187) were analyzed twice (baseline and follow-up, 9-20 years apart). The cases received their T2D diagnose between baseline and follow-up. Prospective (using baseline data) and cross-sectional (using follow-up data) odds ratios (ORs) for T2D on lipid standardized POPs (HCB, p,p'-DDE, ∑DL-PCBs, ∑NDL-PCBs) were estimated using conditional logistic regression, adjusting for body mass index (BMI) and plasma lipids. The influence of BMI, weight-change, and plasma lipids on longitudinal changes in POP concentrations were evaluated among non-diabetic individuals (n = 306).RESULTS: POPs were associated with T2D in both the prospective and cross-sectional assessments. Of a standard deviation increase in POPs, prospective ORs ranged 1.42 (95% CI: 0.99, 2.06) for ∑NDL-PCBs to 1.55 (95% CI: 1.01, 2.38) for HCB (p < 0.05 only for HCB), and cross-sectional ORs ranged 1.62 (95% CI: 1.13; 2.32) for p,p'-DDE to 2.06 (95% CI: 1.29, 3.28) for ∑DL-PCBs (p < 0.05 for all POPs). In analyses of non-diabetic individuals, higher baseline BMI, decreased weight and decreased plasma lipid concentrations were associated with a slower decrease of POPs. Cases had, besides a higher BMI, reduced cholesterol and weight gain at follow-up compared to controls, which can explain the higher ORs in the cross-sectional assessments.DISCUSSION: The association between POPs and T2D was confirmed, but an indication that individuals body fat history might influence POP-T2D associations weakens the epidemiological support for a causal association. It also warrants studies based on other exposure metrics than biomonitoring. In addition, we note that a cross-sectional design overestimates the ORs if T2D cases have successfully intervened on weight and/or blood lipids, as changes in these factors cause changes in POPs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Biomonitoring
- Longitudinal data
- POPs
- Polychlorinated biphenyl congeners
- Type 2 diabetes
- Biomonitoring
- Longitudinal data
- Polychlorinated biphenyl congeners
- POPs
- Type 2 diabetes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tornevi, Andreas
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Sommar, Johan
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Rantakokko, Panu
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Bergdahl, Ingvar ...
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Donat-Vargas, Ca ...
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Kiviranta, Hannu
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visa fler...
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Rolandsson, Olov
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Rylander, Lars
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Wennberg, Maria, ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Environmental Re ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet
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Lunds universitet