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Peri-implant crevic...
Peri-implant crevicular fluid proteome before and after adjunctive enamel matrix derivative treatment of peri-implantitis
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- Esberg, Anders (författare)
- Umeå universitet,Institutionen för odontologi,Umea Univ, Dept Odontol, Umea, Sweden
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- Isehed, Catrine (författare)
- Uppsala universitet,Umeå universitet,Institutionen för odontologi,Department of Periodontology, Public Dental Health County Council of Gävleborg, Gävle County Hospital, Gävle, Sweden; Center for Clinical Research and Development, Uppsala University/Region Gävleborg, Gävle, Sweden,Centrum för klinisk forskning, Gävleborg,Umea Univ, Dept Mol Periodontol, Umea, Sweden;Gavle Cty Hosp, Publ Dent Hlth Cty Council Gavleborg, Dept Periodontol, Gavle, Sweden
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- Holmlund, Anders (författare)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Gavle Cty Hosp, Publ Dent Hlth Cty Council Gavleborg, Dept Periodontol, Gavle, Sweden
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- Lundberg, Pernilla, 1965- (författare)
- Umeå universitet,Institutionen för odontologi,Umea Univ, Dept Mol Periodontol, Umea, Sweden
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(creator_code:org_t)
- 2019-05-20
- 2019
- Engelska.
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Ingår i: Journal of Clinical Periodontology. - : John Wiley & Sons. - 0303-6979 .- 1600-051X. ; 46:6, s. 669-677
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Aim: The aim of this study was to explore which peri‐implant crevicular fluid (PICF) protein pattern is associated with the active peri‐implantitis process.Materials and methods: Peri‐implant crevicular fluid from 25 peri‐implantitis sites were subjected to proteomic analysis using liquid chromatography–tandem mass spectrometry before and at 3, 6 and 12 months after treatment, to identify associations between PICF protein pattern and implant loss, bleeding on probing, pocket depth and enamel matrix derivative (EMD) treatment.Results: Clustering of subjects based on their 3–12 months PICF proteomic profiles by principal component analysis defined two major clusters. Cluster 2 differentiated from cluster 3 by 52 proteins (R2 = 90%, Q2 = 80%) and belonging to cluster 2 was associated with implant loss (p = 0.009) and bleeding on probing (p = 0.001). Cluster 3 was associated with implant survival and EMD treatment (p = 0.044).Conclusion: Here, we demonstrate that a specific PICF proteomic profile associates with active peri‐implantitis process and implant loss.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- enamel matrix derivative
- implant
- peri-implantitis
- proteome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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