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Renal clearance of ...
Renal clearance of heparin-binding protein and elimination during renal replacement therapy : Studies in ICU patients and healthy volunteers
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- Samuelsson, Line (författare)
- Umeå University,Umeå universitet,Anestesiologi och intensivvård,Department of Surgical and Perioperative Sciences, Anesthesiology and Intensive Care Medicine (Östersund), Umeå University, Umeå, Sweden
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- Tyden, Jonas (författare)
- Umeå University,Umeå universitet,Anestesiologi och intensivvård,Department of Surgical and Perioperative Sciences, Anesthesiology and Intensive Care Medicine (Östersund), Umeå University, Umeå, Sweden
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- Herwald, Heiko (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Department of Clinical Sciences, Lund University, Lund, Sweden
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- Hultin, Magnus, 1968- (författare)
- Umeå University,Umeå universitet,Anestesiologi och intensivvård,Department of Surgical and Perioperative Sciences, Anesthesiology and Intensive Care Medicine, Umeå University, Umeå, Sweden
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- Walldén, Jakob (författare)
- Umeå University,Umeå universitet,Anestesiologi och intensivvård,Department of Surgical and Perioperative Sciences, Anesthesiology and Intensive Care Medicine (Sundsvall) Umeå University, Umeå, Sweden
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- Steinvall, Ingrid, 1959- (författare)
- Linköpings universitet,Linköping University,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US
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- Sjöberg, Folke, 1956- (författare)
- Linköpings universitet,Linköping University,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US,Region Östergötland, Hand- och plastikkirurgiska kliniken US
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- Johansson, Joakim (författare)
- Umeå University,Umeå universitet,Anestesiologi och intensivvård,Department of Surgical and Perioperative Sciences, Anesthesiology and Intensive Care Medicine (Östersund), Umeå University, Umeå, Sweden
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(creator_code:org_t)
- 2019-08-29
- 2019
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 14:8
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Abstract
Ämnesord
Stäng
- BACKGROUND: Heparin-binding protein (HBP) is released by neutrophils upon activation, and elevated plasma levels are seen in inflammatory states like sepsis, shock, cardiac arrest, and burns. However, little is known about the elimination of HBP. We wanted to study renal clearance of HBP in healthy individuals and in burn patients in intensive care units (ICUs). We also wished to examine the levels of HBP in the effluent of renal replacement circuits in ICU patients undergoing continuous renal replacement therapy (CRRT).METHODS: We measured plasma and urine levels of HBP and urine flow rate in 8 healthy individuals and 20 patients in a burn ICU. In 32 patients on CRRT, we measured levels of HBP in plasma and in the effluent of the CRRT circuit.RESULTS: Renal clearance of HBP (median (IQR) ml/min) was 0.19 (0.08-0.33) in healthy individuals and 0.30 (0.01-1.04) in burn ICU patients. In ICU patients with cystatin C levels exceeding 1.44 mg/l, clearance was 0.45 (0.15-2.81), and in patients with cystatin C below 1.44 mg/l clearance was lower 0.28 (0.14-0.55) (p = 0.04). Starting CRRT did not significantly alter plasma levels of HBP (p = 0.14), and the median HBP level in the effluent on CRRT was 9.1 ng/ml (IQR 7.8-14.4 ng/ml).CONCLUSION: In healthy individuals and critically ill burn patients, renal clearance of HBP is low. It is increased when renal function is impaired. Starting CRRT in critically ill patients does not alter plasma levels of HBP significantly, but HBP can be found in the effluent. It seems unlikely that impaired kidney function needs to be considered when interpreting concentrations of HBP in previous studies. Starting CRRT does not appear to be an effective way of reducing HBP concentrations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
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Samuelsson, Line
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Tyden, Jonas
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Herwald, Heiko
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Hultin, Magnus, ...
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Walldén, Jakob
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Steinvall, Ingri ...
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Sjöberg, Folke, ...
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Johansson, Joaki ...
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Umeå universitet
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