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Nfkb 1 is dispensab...
Nfkb 1 is dispensable for Myc-induced lymphomagenesis.
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Keller, Ulrich (författare)
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- Nilsson, Jonas A (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Nilsson
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Maclean, Kirsteen H (författare)
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Old, Jennifer B (författare)
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Cleveland, John L (författare)
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Oncogene. - 0950-9232. ; 24:41, s. 6231-40
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Rel/NF-kappaB transcription factors are critical arbiters of immune responses, cell survival, and transformation, and are frequently deregulated in cancer. The p50 NF-kappaB 1 component of Rel/NF-kappaB DNA-binding dimers regulates genes involved in both cell cycle traverse and apoptosis. Nfkb 1 loss accelerates B cell growth and leads to increased B cell turnover in vivo, phenotypes akin to those manifested in B cells of Emu-Myc transgenic mice, a model of human Burkitt lymphoma. Interestingly, Emu-Myc B cells express reduced levels of cytoplasmic and nuclear NF-kappaB 1 and have reduced Rel/NF-kappaB DNA-binding activity, suggesting that Myc-mediated repression of NF-kappaB 1 might mediate its proliferative and apoptotic effects on B cells. Furthermore, Nfkb 1 expression was reduced in the majority of Emu-Myc lymphomas and was also suppressed in human Burkitt lymphoma. Nonetheless, loss of Nfkb 1 did not appreciably affect Myc's proliferative or apoptotic responses in B cells and had no effect on lymphoma development in Emu-Myc mice. Therefore, Nfkb 1 is dispensable for Myc-induced lymphomagenesis.. Oncogene (2005) 24, 6231-6240
Nyckelord
- Animals
- Base Sequence
- Burkitt Lymphoma/genetics
- DNA/metabolism
- DNA Primers
- Humans
- Mice
- Mice; Inbred C57BL
- Mice; Knockout
- Mice; Transgenic
- NF-kappa B p50 Subunit/genetics/*physiology
- Proto-Oncogene Proteins c-myc/genetics/*physiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Oncogene
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