Mnt : master regulator of the Max network.

• Recent findings indicate that we should rethink how Myc oncoproteins transactivate their target genes. It appears that Mnt, a transcription factor that mediates transrepression at Myc's E-boxes, plays a crucial role in keeping the cell cycle in check. By removing Mnt, either via conventional knockout techniques or via RNA interference, cells become hyper-proliferative, susceptible to apoptosis and can be transformed by Ras--all hallmarks of Myc overexpression. These findings indicate that Myc's ability to function as an oncogene may rely, at least in part, on its ability to effectively antagonize Mnt's transrepression and tumor suppressor functions.

Nyckelord

Animals

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

Basic-Leucine Zipper Transcription Factors

DNA-Binding Proteins/genetics/*metabolism

Fibroblasts/cytology/metabolism

Gene Expression Regulation

Mice

Mice; Knockout

Proto-Oncogene Proteins c-myc/*metabolism

RNA Interference

Repressor Proteins/genetics/*metabolism

Transcription Factors/genetics/*metabolism

Publikations- och innehållstyp

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