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Electronic cigarett...
Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers
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- Mobarrez, Fariborz (författare)
- Uppsala universitet,Klinisk kemi
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- Antoniewicz, Lukasz (författare)
- Karolinska Inst, Danderyd Univ Hosp, Dept Clin Sci, Div Internal Med, Stockholm, Sweden
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- Hedman, Linnea, 1979- (författare)
- Umeå universitet,Avdelningen för hållbar hälsa,Umeå Univ, Dept Publ Hlth & Clin Med, OLIN Unit, Sect Sustainable Hlth, Umeå, Sweden
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- Bosson, Jenny A., 1975- (författare)
- Umeå universitet,Lungmedicin,Umeå Univ, Dept Publ Hlth & Clin Med, Div Med Resp Med, Umeå, Sweden
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- Lundbäck, Magnus (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- Engelska.
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Ingår i: Atherosclerosis. - : Elsevier. - 0021-9150 .- 1879-1484. ; 301, s. 93-100
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://www.atheroscl...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND AND AIMS: E-cigarette use is increasingly common. Whether e-cigarettes are harmful to human health is an intensely debated subject. In order to investigate whether e-cigarettes with and without nicotine cause different vascular responses, we obtained blood samples from healthy young volunteers who performed brief active e-cigarette inhalations. Extracellular vesicles (EVs) of endothelial and platelet origin were measured to determine vascular changes.METHODS: Using a randomized, double-blind, crossover design, 17 healthy occasional smokers inhaled 30 puffs of e-cigarette vapor during 30 min. Blood samples were collected at baseline, as well as at 0, 2, 4 and 6 h post-exposure. EVs from platelets and endothelial cells were measured by flow cytometry.RESULTS: Platelet and endothelial derived EVs were significantly increased with peak levels seen at 4 h following exposure to active inhalation of e-cigarette vapor with nicotine. Moreover, platelet derived EVs, expressing platelet activation marker P-selectin and the inflammation marker, CD40 ligand, were also significantly increased following inhalation of e-cigarette vapor with nicotine. In addition, platelet derived EVs expressing CD40 ligand was increased after inhalation of e-cigarette vapor without nicotine.CONCLUSION: As few as 30 puffs of nicotine-containing e-cigarette vapor caused an increase in levels of circulating EVs of endothelial and platelet origin, which may signify underlying vascular changes. Although e-cigarette vapor without nicotine caused an increase in platelet EVs expressing CD40 ligand, nicotine, as a component in the vapor, seems to have a more compelling effect on extracellular vesicle formation and protein composition.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Electronic cigarette
- Endothelial microvesicles
- Extracellular vesicles
- Microparticles
- Platelet microvesicles
- e-cigarette
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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