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Transplantation-fre...
Transplantation-free survival after Norwood surgery for hypoplastic left heart syndrome with aortic atresia : A Swedish national cohort study
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Öhman, Annika (författare)
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El-Segaier, Milad (författare)
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- Bergman, Gunnar (författare)
- Karolinska Institutet
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Hanseus, Katarina (författare)
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Malm, Torsten (författare)
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Nilsson, Boris (författare)
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Pivodic, Aldina (författare)
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- Rydberg, Annika (författare)
- Umeå universitet,Pediatrik
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- Sonesson, Sven-Erik (författare)
- Karolinska Institutet
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Mellander, Mats (författare)
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(creator_code:org_t)
- Cambridge University Press, 2020
- 2020
- Engelska.
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Ingår i: Cardiology in the Young. - : Cambridge University Press. - 1047-9511 .- 1467-1107. ; 30:3, s. 353-360
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Norwood surgery has been available in Sweden since 1993. In this national cohort study, we analysed transplantation-free survival after Norwood surgery for hypoplastic left heart syndrome with aortic atresia. Methods: Patients were identified from the complete national cohort of live-born with hypoplastic left heart syndrome/aortic atresia 1993-2010. Analysis of survival after surgery was performed using Cox proportional hazards models for the total cohort and for birth period and gender separately. Thirty-day mortality and inter-stage mortality were analysed. Patients were followed until September 2016. Results: The 1993-2010 cohort consisted of 208 live-born infants. Norwood surgery was performed in 121/208 (58%). The overall transplantation-free survival was 61/121 (50%). The survival was higher in the late period (10-year survival 63%) than in the early period (10-year survival 40%) (p = 0.010) and lower for female (10-year survival 34%) than for male patients (10-year survival 59%) (p = 0.002). Inter-stage mortality between stages I and II decreased from 23 to 8% (p = 0.008). For male patients, low birthweight in relation to gestational age was a factor associated with poor outcome. Conclusion: The survival after Norwood surgery for hypoplastic left heart syndrome/aortic atresia improved by era of surgery, mainly explained by improved survival between stages I and II. Female gender was a significant risk factor for death or transplantation. For male patients, there was an increased risk of death when birthweight was lower than expected in relation to gestational age.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Hypoplastic left heart syndrome
- transplantation-free survival
- risk factors
- inter-stage mortality
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Öhman, Annika
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El-Segaier, Mila ...
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Bergman, Gunnar
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Hanseus, Katarin ...
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Malm, Torsten
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Nilsson, Boris
-
visa fler...
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Pivodic, Aldina
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Rydberg, Annika
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Sonesson, Sven-E ...
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Mellander, Mats
-
visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Cardiology in th ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet