Sökning: id:"swepub:oai:DiVA.org:umu-175507" >
Establishment of Pr...
Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase
-
- Karlsson, Richard (författare)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Division of Experimental Cancer Research, Department of Translational Medicine, Lund University, Clinical Research Centre, Malmö, Sweden,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine
-
- Larsson, Per (författare)
- Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),University of Copenhagen
-
- Miftakhova, Regina R. (författare)
- Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Genetics, Kazan Federal University, Kazan, Russia
-
visa fler...
-
- Khaja, Azharuddin Sajid Syed (författare)
- Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
-
- Sarwar, Martuza (författare)
- Lund University,Lunds universitet,Experimentell cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Experimental Cancer Research, Malmö,Lund University Research Groups
-
- Semenas, Julius (författare)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Division of Experimental Cancer Research, Department of Translational Medicine, Lund University, Clinical Research Centre, Malmö, Sweden,Experimentell cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Experimental Cancer Research, Malmö,Lund University Research Groups
-
- Chen, Sa, 1967- (författare)
- Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
-
- Hedblom, Andreas (författare)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Division of Experimental Cancer Research, Department of Translational Medicine, Lund University, Clinical Research Centre, Malmö, Sweden,Experimentell cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Experimental Cancer Research, Malmö,Lund University Research Groups
-
- Wang, Tianyan (författare)
- Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
-
- Ekström-Holka, Kristina (författare)
- Lund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molecular Pathology, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
-
- Simoulis, Athanasios (författare)
- Skåne University Hospital
-
- Kumar, Anjani (författare)
- Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
-
- Ødum, Nils (författare)
- University of Copenhagen
-
- Grundström, Thomas (författare)
- Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
-
- Persson, Jenny L., Professor (författare)
- Lund University,Lunds universitet,Umeå University,Malmö University,Malmö universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Division of Experimental Cancer Research, Department of Translational Medicine, Lund University, Clinical Research Centre, Malmö, Sweden; Department of Biomedical Sciences, Malmö University, Malmö, Sweden,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Experimentell cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Experimental Cancer Research, Malmö,Lund University Research Groups
-
visa färre...
-
(creator_code:org_t)
- 2020-09-22
- 2020
- Engelska.
-
Ingår i: Cancers. - : MDPI. - 2072-6694. ; 12:9
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://www.mdpi.com...
-
https://mau.diva-por... (primary) (Raw object)
-
http://dx.doi.org/10... (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- Cancer cells facilitate growth and metastasis by using multiple signals from the cancer-associated microenvironment. However, it remains poorly understood whether prostate cancer (PCa) cells may recruit and utilize bone marrow cells for their growth and survival. Furthermore, the regulatory mechanisms underlying interactions between PCa cells and bone marrow cells are obscure. In this study, we isolated bone marrow cells that mainly constituted populations that were positive for CD11b and Gr1 antigens from xenograft PC-3 tumor tissues from athymic nu/nu mice. We found that the tumor-infiltrated cells alone were unable to form tumor spheroids, even with increased amounts and time. By contrast, the tumor-infiltrated cells together with PCa cells formed large numbers of tumor spheroids compared with PCa cells alone. We further utilized xenograft athymic nu/nu mice bearing bone metastatic lesions. We demonstrated that PCa cells were unable to survive and give rise to colony-forming units (CFUs) in media that were used for hematopoietic cell colony-formation unit (CFU) assays. By contrast, PC-3M cells survived when bone marrow cells were present and gave rise to CFUs. Our results showed that PCa cells required bone marrow cells to support their growth and survival and establish bone metastasis in the host environment. We showed that PCa cells that were treated with either siRNA for PIP5K1α or its specific inhibitor, ISA-2011B, were unable to survive and produce tumor spheroids, together with bone marrow cells. Given that the elevated expression of PIP5K1α was specific for PCa cells and was associated with the induced expression of VEGF receptor 2 in PCa cells, our findings suggest that cancer cells may utilize PIP5K1α-mediated receptor signaling to recruit growth factors and ligands from the bone marrow-derived cells. Taken together, our study suggests a new mechanism that enables PCa cells to gain proliferative and invasive advantages within their associated host microenvironment. Therapeutic interventions using PIP5K1α inhibitors may not only inhibit tumor invasion and metastasis but also enhance the host immune system.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- prostate cancer metastasis
- bone marrow cells
- PIP5K1α
- therapeutic interventions
- biomedical laboratory science
- biomedicinsk laboratorievetenskap
- Bone marrow cells
- PIP5K1α
- Prostate cancer metastasis
- Therapeutic interventions
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Cancers
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Karlsson, Richar ...
-
Larsson, Per
-
Miftakhova, Regi ...
-
Khaja, Azharuddi ...
-
Sarwar, Martuza
-
Semenas, Julius
-
visa fler...
-
Chen, Sa, 1967-
-
Hedblom, Andreas
-
Wang, Tianyan
-
Ekström-Holka, K ...
-
Simoulis, Athana ...
-
Kumar, Anjani
-
Ødum, Nils
-
Grundström, Thom ...
-
Persson, Jenny L ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Klinisk laborato ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Cancers
- Av lärosätet
-
Umeå universitet
-
Malmö universitet
-
Lunds universitet