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The influence of co...
The influence of common polygenic risk and gene sets on social skills group training response in autism spectrum disorder
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- Li, Danyang (författare)
- Karolinska Institutet
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- Choque-Olsson, Nora (författare)
- Karolinska Inst, Ctr Psychiat Res, Ctr Neurodev Disorders KIND, Stockholm Cty Council,Dept Womens & Childrens Hlt, Stockholm, Sweden.;Stockholm Hlth Care Serv, Reg Stockholm, Child & Adolescent Psychiat, Stockholm, Sweden.;Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden.;Stockholm Hlth Care Serv, Reg Stockholm, Stockholm, Sweden.
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- Jiao, Hong (författare)
- Karolinska Institutet
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- Norgren, Nina (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Univ, Dept Mol Biol, Sci Life Lab, Natl Bioinformat Infrastruct Sweden NBIS, S-90187 Umeå, Sweden.
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- Jonsson, Ulf, 1974- (författare)
- Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst, Ctr Psychiat Res, Ctr Neurodev Disorders KIND, Stockholm Cty Council,Dept Womens & Childrens Hlt, Stockholm, Sweden.;Stockholm Hlth Care Serv, Reg Stockholm, Child & Adolescent Psychiat, Stockholm, Sweden.
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- Bölte, Sven (författare)
- Karolinska Institutet
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- Tammimies, Kristiina (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Ctr Psychiat Res, Ctr Neurodev Disorders KIND, Stockholm Cty Council,Dept Womens & Childrens Hlt, Stockholm, Sweden;Stockholm Hlth Care Serv, Reg Stockholm, Child & Adolescent Psychiat, Stockholm, Sweden.;Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden.;Stockholm Hlth Care Serv, Reg Stockholm, Stockholm, Sweden. (creator_code:org_t)
- 2020-10-12
- 2020
- Engelska.
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Ingår i: NPJ Genomic Medicine. - : Nature Publishing Group. - 2056-7944. ; 5:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Social skills group training (SSGT) is a frequently used behavioral intervention in autism spectrum disorder (ASD), but the effects are moderate and heterogeneous. Here, we analyzed the effect of polygenic risk score (PRS) and common variants in gene sets on the intervention outcome. Participants from the largest randomized clinical trial of SSGT in ASD to date were selected (N = 188, 99 from SSGT, 89 from standard care) to calculate association between the outcomes in the SSGT trial and PRSs for ASD, attention-deficit hyperactivity disorder (ADHD), and educational attainment. In addition, specific gene sets were selected to evaluate their role on intervention outcomes. Among all participants in the trial, higher PRS for ADHD was associated with significant improvement in the outcome measure, the parental-rated Social Responsiveness Scale. The significant association was due to better outcomes in the standard care group for individuals with higher PRS for ADHD (post-intervention: β = −4.747, P = 0.0129; follow-up: β = −5.309, P = 0.0083). However, when contrasting the SSGT and standard care group, an inferior outcome in the SSGT group was associated with higher ADHD PRS at follow-up (β = 6.67, P = 0.016). Five gene sets within the synaptic category showed a nominal association with reduced response to interventions. We provide preliminary evidence that genetic liability calculated from common variants could influence the intervention outcomes. In the future, larger cohorts should be used to investigate how genetic contribution affects individual response to ASD interventions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- art (ämneskategori)
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