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Smad7 Enhances TGF-...
Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells
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- Thakur, Noopur (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab
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- Hamidi, Anahita (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Ludwig Inst Canc Res Ltd,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Song, Jie, 1984- (författare)
- Umeå universitet,Patologi,Umeå Univ, Dept Med Biosci, S-90187 Umeå, Sweden.
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- Itoh, Susumu (författare)
- Showa Pharmaceutical University, Tokyo, Japan,Showa Pharmaceut Univ, Lab Biochem, Tokyo 1948543, Japan.
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- Bergh, Anders (författare)
- Umeå universitet,Patologi,Umeå Univ, Dept Med Biosci, S-90187 Umeå, Sweden.
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- Heldin, Carl-Henrik, 1952- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Sci Life Lab, Ludwig Inst Canc Res Ltd, Box 595, S-75124 Uppsala, Sweden.;Uppsala Univ, Sci Life Lab, Dept Med Biochem & Microbiol, Box 582, S-75123 Uppsala, Sweden.
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- Landström, Maréne (författare)
- Uppsala universitet,Umeå universitet,Patologi,Uppsala University,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Sci Life Lab, Ludwig Inst Canc Res Ltd, Box 595, S-75124 Uppsala, Sweden.;Umeå Univ, Dept Med Biosci, S-90187 Umeå, Sweden.
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(creator_code:org_t)
- Cell Press, 2020
- 2020
- Engelska.
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Ingår i: iScience. - : Cell Press. - 2589-0042. ; 23:9
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Transforming growth factor β (TGF-β) enhances migration and invasion of cancer cells, causing life-threatening metastasis. Smad7 expression is induced by TGF-β to control TGF-β signaling in a negative feedback manner. Here we report an additional function of Smad7, i.e., to enhance TGF-β induction of c-Jun and HDAC6 via binding to their regulatory regions, promoting migration and invasion of prostate cancer cells. Lysine 102 in Smad7 is crucial for binding to specific consensus sites in c-Jun and HDAC6, even when endogenous Smad2, 3, and 4 were silenced by siRNA. A correlation between the mRNA expression of Smad7 and HDAC6, Smad7 and c-Jun, and c-Jun and HDAC6 was found in public databases from analyses of prostate cancer tissues. High expression of Smad7, HDAC6, and c-Jun correlated with poor prognosis for patients with prostate cancer. The knowledge that Smad7 can activate transcription of proinvasive genes leading to prostate cancer progression provides clinically relevant information.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cancer
- Cell Biology
- Molecular Biology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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