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Activity of airway ...
Activity of airway antimicrobial peptides against cystic fibrosis pathogens
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- Cabak, Andrea (författare)
- Lund University
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- Hovold, Gisela (författare)
- Lund University,Lunds universitet,Luftvägar, patogener, immunförsvar,Forskargrupper vid Lunds universitet,Airways, pathogens, innate immunity,Lund University Research Groups
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- Petersson, Ann Cathrine (författare)
- Regional Laboratories Region Skåne
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- Ramstedt, Madeleine (författare)
- Umeå University,Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)
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- Påhlman, Lisa I. (författare)
- Lund University,Lunds universitet,Luftvägar, patogener, immunförsvar,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Airways, pathogens, innate immunity,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital
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(creator_code:org_t)
- 2020-08-28
- 2020
- Engelska.
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Ingår i: Pathogens and Disease. - : Oxford University Press. - 2049-632X. ; 78:7
- Relaterad länk:
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https://academic.oup...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Antimicrobial peptides are important players of the innate host defence against invading microorganisms. The aim of this study was to evaluate the activity of airway antimicrobial peptides against the common cystic fibrosis (CF) pathogen Pseudomonas aeruginosa, and to compare it to the emerging multi-drug resistant CF pathogens Achromobacter xylosoxidans and Stenotrophomonas maltophilia. Clinical bacterial isolates from CF patients were used, and the antimicrobial activity of human beta-defensin 2 and 3, LL37 and lysozyme was evaluated using radial diffusion assay and viable counts. The cell surface zeta potential was analysed to estimate the net charge at the bacterial surface. Of the bacterial species included in the study, A. xylosoxidans was the most resistant to antimicrobial peptides, whereas P. aeruginosa was the most susceptible. The net charge of the bacterial surface was significantly more negative for P. aeruginosa compared to A. xylosoxidans, which may in part explain the differences in susceptibility.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- antimicrobial peptides
- resistance
- cystic fibrosis
- innate immunity
- Pseudomonas aeruginosa
- achromobacter xylosoxidans
- achromobacter xylosoxidans
- Pseudomonas aeruginosa
- antimicrobial peptides
- cystic fibrosis
- innate immunity
- resistance
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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