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NKT cells promote b...
NKT cells promote both type 1 and type 2 inflammatory responses in a mouse model of liver fibrosis
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- Nilsson, Julia (författare)
- Lund University,Lunds universitet,Autoimmunitet,Forskargrupper vid Lunds universitet,Autoimmunity,Lund University Research Groups,InfiCure Bio AB
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- Hörnberg, Maria (författare)
- InfiCure Bio AB
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- Schmidt-Christensen, Anja (författare)
- Lund University,Lunds universitet,Autoimmunitet,Forskargrupper vid Lunds universitet,Autoimmunity,Lund University Research Groups
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- Linde, Kajsa (författare)
- InfiCure Bio AB
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- Nilsson, Maria (författare)
- Lund University
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- Carlus, Marine (författare)
- Carlus Pathology Consulting
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- Erttmann, Saskia F. (författare)
- Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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- Mayans, Sofia (författare)
- InfiCure Bio AB
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- Holmberg, Dan (författare)
- Lund University,Lunds universitet,Autoimmunitet,Forskargrupper vid Lunds universitet,Autoimmunity,Lund University Research Groups,InfiCure Bio AB
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(creator_code:org_t)
- 2020-12-11
- 2020
- Engelska.
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Ingår i: Scientific Reports. - : Nature Research. - 2045-2322. ; 10:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Sterile liver inflammation and fibrosis are associated with many liver disorders of different etiologies. Both type 1 and type 2 inflammatory responses have been reported to contribute to liver pathology. However, the mechanisms controlling the balance between these responses are largely unknown. Natural killer T (NKT) cells can be activated to rapidly secrete cytokines and chemokines associated with both type 1 and type 2 inflammatory responses. As these proteins have been reported to accumulate in different types of sterile liver inflammation, we hypothesized that these cells may play a role in this pathological process. We have found that a transgenic NKT (tgNKT) cell population produced in the immunodeficient 2,4αβNOD.Rag2−/− mice, but not in 2,4αβNOD.Rag2+/− control mice, promoted a type 1 inflammatory response with engagement of the NOD-, LRR- and pyrin domain-containing protein-3 (NLRP3) inflammasome. The induction of the type 1 inflammatory response was followed by an altered cytokine profile of the tgNKT cell population with a biased production of anti-inflammatory/profibrotic cytokines and development of liver fibrosis. These findings illustrate how the plasticity of NKT cells modulates the inflammatory response, suggesting a key role for the NKT cell population in the control of sterile liver inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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