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Effect of Integrate...
Effect of Integrated, Person-Centred Palliative Advanced Home and Heart Failure Care on NT-proBNP Levels : A Substudy of the PREFER Study
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Fryxell, Jenni (författare)
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- Olofsson, Mona, 1952- (författare)
- Umeå universitet,Avdelningen för medicin,Research Unit, Medicine-Geriatric Clinic, Skellefteå Hospital, Skellefteå, Sweden
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- Brännström, Margareta (författare)
- Umeå universitet,Institutionen för omvårdnad,Campus Skellefteå, Skellefteå, Sweden
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- Boman, Kurt (författare)
- Umeå universitet,Avdelningen för medicin,Research Unit, Medicine-Geriatric Clinic, Skellefteå Hospital, Skellefteå, Sweden
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(creator_code:org_t)
- Scientific Research Publishing, 2021
- 2021
- Engelska.
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Ingår i: World Journal of Cardiovascular Diseases. - : Scientific Research Publishing. - 2164-5329 .- 2164-5337. ; 11:1, s. 1-10
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https://doi.org/10.4...
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https://umu.diva-por... (primary) (Raw object)
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http://www.scirp.org...
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- Objective: In 2012, we initiated a new person-centred model, integrated Palliative advanced home caRE and heart FailurE caRe (PREFER), to integrate specialised palliative home care with heart failure care. Natriuretic peptide-guided treatment is valuable for younger patients (age < 75 years), but its usefulness in palliative care is uncertain. We explored whether patients in PREFER reduced mean level of N-terminal pro B-type natriuretic peptide (NT-proBNP) more than the control group.Design: A pre-specified, exploratory substudy, analysed within the prospective, randomised PREFER study, which had an open, non-blinded design.Participants: Patients in palliative care with chronic heart failure, New York Heart Association class III-IV were randomly assigned to an intervention (n = 36; 26 males, 10 females, mean age: 81.9 years) or control group (n = 36; 25 males, 11 females, mean age:76.5 years). The intervention group received the PREFER intervention for 6 months. The control group received care as usual at a primary health care centre or heart failure clinic at the hospital. NT-proBNP was measured at the start and end of study.Results: Plasma levels of NT-proBNP differed significantly between groups at baseline. By the end of the study, no significant difference was found between the groups. The mean value for NT-proBNP decreased by 35% in the PREFER group but was not statistically significant (P = 0.074); NT-proBNP increased 4% in the control group.Conclusions: We found no statistically significant reductions of NT-proBNP levels neither between nor within the PREFER and the control group at the end of the study.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Nyckelord
- Chronic Heart Failure
- Palliative Care
- Integrated Care
- NT-proBNP
- Elderly
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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