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Sökning: id:"swepub:oai:DiVA.org:umu-180481" > Positron Emission T...

Positron Emission Tomography Imaging of the Endocannabinoid System : Opportunities and Challenges in Radiotracer Development

Hou, Lu (författare)
Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, 613 West Huangpu Road, Tianhe District, Guangzhou, China
Rong, Jian (författare)
Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, MA, Boston, United States
Haider, Ahmed (författare)
Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, MA, Boston, United States
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Ogasawara, Daisuke (författare)
The Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, SR107, 10550 North Torrey Pines Road, CA, San diego, United States
Varlow, Cassis (författare)
Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, Department of Psychiatry, Institute of Medical Science, University of Toronto, 250 College Street, ON, Toronto, Canada
Schafroth, Michael A. (författare)
The Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, SR107, 10550 North Torrey Pines Road, CA, San diego, United States
Mu, Linjing (författare)
Center for Radiopharmaceutical Sciences of ETH, PSI, USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, Zurich, Switzerland
Gan, Jiefeng (författare)
Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, 613 West Huangpu Road, Tianhe District, Guangzhou, China
Xu, Hao (författare)
Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, 613 West Huangpu Road, Tianhe District, Guangzhou, China
Fowler, Christopher J. (författare)
Umeå universitet,Institutionen för farmakologi och klinisk neurovetenskap
Zhang, Ming-Rong (författare)
Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Japan
Vasdev, Neil (författare)
Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, MA, Boston, United States; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, Department of Psychiatry, Institute of Medical Science, University of Toronto, 250 College Street, ON, Toronto, Canada
Ametamey, Simon (författare)
Center for Radiopharmaceutical Sciences of ETH, PSI, USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, Zurich, Switzerland
Cravatt, Benjamin F. (författare)
The Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, SR107, 10550 North Torrey Pines Road, CA, San diego, United States
Wang, Lu (författare)
Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, 613 West Huangpu Road, Tianhe District, Guangzhou, China; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, MA, Boston, United States
Liang, Steven H. (författare)
Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, MA, Boston, United States
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 (creator_code:org_t)
2020-12-31
2021
Engelska.
Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 64:1, s. 123-149
Relaterad länk:
https://www.ncbi.nlm...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • The endocannabinoid system (ECS) is involved in a wide range of biological functions and comprises cannabinoid receptors and enzymes responsible for endocannabinoid synthesis and degradation. Over the past 2 decades, significant advances toward developing drugs and positron emission tomography (PET) tracers targeting different components of the ECS have been made. Herein, we summarized the recent development of PET tracers for imaging cannabinoid receptors 1 (CB1R) and 2 (CB2R) as well as the key enzymes monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), particularly focusing on PET neuroimaging applications. State-of-the-art PET tracers for the ECS will be reviewed including their chemical design, pharmacological properties, radiolabeling, as well as preclinical and human PET imaging. In addition, this review addresses the current challenges for ECS PET biomarker development and highlights the important role of PET ligands to study disease pathophysiology as well as to facilitate drug discovery.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

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