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A ketogenic low‐car...
A ketogenic low‐carbohydrate high‐fat diet increases ldl cholesterol in healthy, young, normal‐weight women : A randomized controlled feeding trial
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- Burén, Jonas (författare)
- Umeå universitet,Institutionen för kost- och måltidsvetenskap,Avdelningen för medicin
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- Ericsson, Madelene (författare)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM),Fysiologisk kemi
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- Damasceno, Nágila Raquel Teixeira (författare)
- Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil
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- Sjödin, Anna (författare)
- Umeå universitet,Institutionen för kost- och måltidsvetenskap
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(creator_code:org_t)
- 2021-03-02
- 2021
- Engelska.
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 13:3, s. 1-12
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Ketogenic low‐carbohydrate high‐fat (LCHF) diets are popular among young, healthy, normal‐weight individuals for various reasons. We aimed to investigate the effect of a ketogenic LCHF diet on low‐density lipoprotein (LDL) cholesterol (primary outcome), LDL cholesterol sub-fractions and conventional cardiovascular risk factors in the blood of healthy, young, and nor-mal‐weight women. The study was a randomized, controlled, feeding trial with crossover design. Twenty‐four women were assigned to a 4 week ketogenic LCHF diet (4% carbohydrates; 77% fat; 19% protein) followed by a 4 week National Food Agency recommended control diet (44% carbo-hydrates; 33% fat; 19% protein), or the reverse sequence due to the crossover design. Treatment periods were separated by a 15 week washout period. Seventeen women completed the study and treatment effects were evaluated using mixed models. The LCHF diet increased LDL cholesterol in every woman with a treatment effect of 1.82 mM (p < 0.001). In addition, Apolipoprotein B‐100 (ApoB), small, dense LDL cholesterol as well as large, buoyant LDL cholesterol increased (p < 0.001, p < 0.01, and p < 0.001, respectively). The data suggest that feeding healthy, young, normal‐weight women a ketogenic LCHF diet induces a deleterious blood lipid profile. The elevated LDL cholesterol should be a cause for concern in young, healthy, normal‐weight women following this kind of LCHF diet.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Cardiovascular disease
- Diet intervention
- Dietary fat
- Female
- Lipoproteins
- Saturated fatty acids
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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