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Middle cerebral art...
Middle cerebral artery pressure laterality in patients with symptomatic ICA stenosis
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- Holmgren, Madelene (författare)
- Umeå universitet,Radiofysik
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- Stoverud, Karen-Helene (författare)
- Umeå universitet,Radiofysik
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- Zarrinkoob, Laleh (författare)
- Umeå universitet,Neurovetenskaper,Anestesiologi och intensivvård
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- Wåhlin, Anders (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Radiofysik
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- Malm, Jan, Professor, 1957- (författare)
- Umeå universitet,Neurovetenskaper
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- Eklund, Anders, 1965- (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Radiofysik
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(creator_code:org_t)
- 2021-01-08
- 2021
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 16:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- An internal carotid artery (ICA) stenosis can potentially decrease the perfusion pressure to the brain. In this study, computational fluid dynamics (CFD) was used to study if there was a hemispheric pressure laterality between the contra- and ipsilateral middle cerebral artery (MCA) in patients with a symptomatic ICA stenosis. We further investigated if this MCA pressure laterality (ΔPMCA) was related to the hemispheric flow laterality (ΔQ) in the anterior circulation, i.e., ICA, proximal MCA and the proximal anterior cerebral artery (ACA). Twenty-eight patients (73±6 years, range 59–80 years, 21 men) with symptomatic ICA stenosis were included. Flow rates were measured using 4D flow MRI data (PC-VIPR) and vessel geometries were obtained from computed tomography angiography. The ΔPMCA was calculated from CFD, where patient-specific flow rates were applied at all input- and output boundaries. The ΔPMCA between the contra- and ipsilateral side was 6.4±8.3 mmHg (p<0.001) (median 3.9 mmHg, range -1.3 to 31.9 mmHg). There was a linear correlation between the ΔPMCA and ΔQICA (r = 0.85, p<0.001) and ΔQACA (r = 0.71, p<0.001), respectively. The correlation to ΔQMCA was weaker (r = 0.47, p = 0.011). In conclusion, the MCA pressure laterality obtained with CFD, is a promising physiological biomarker that can grade the hemodynamic disturbance in patients with a symptomatic ICA stenosis.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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