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Cortical connectivi...
Cortical connectivity of the nucleus basalis of Meynert in Parkinson's disease and Lewy body dementias
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- Oswal, Ashwini (författare)
- Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom; Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, London, United Kingdom
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- Gratwicke, James (författare)
- Department of Clinical and Movement Neurosciences, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
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- Akram, Harith (författare)
- Department of Clinical and Movement Neurosciences, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
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- Jahanshahi, Marjan (författare)
- Department of Clinical and Movement Neurosciences, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
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- Zaborszky, Laszlo (författare)
- Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, United States
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- Brown, Peter (författare)
- Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom
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- Hariz, Marwan (författare)
- Umeå universitet,Neurovetenskaper,Department of Clinical and Movement Neurosciences, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
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- Zrinzo, Ludvic (författare)
- Department of Clinical and Movement Neurosciences, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
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- Foltynie, Tom (författare)
- Department of Clinical and Movement Neurosciences, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
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- Litvak, Vladimir (författare)
- Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, London, United Kingdom
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(creator_code:org_t)
- 2020-12-26
- 2021
- Engelska.
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Ingår i: Brain. - : Oxford University Press. - 0006-8950 .- 1460-2156. ; 144:3, s. 781-788
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are related conditions that are associated with cholinergic system dysfunction. Dysfunction of the nucleus basalis of Meynert (NBM), a basal forebrain structure that provides the dominant source of cortical cholinergic innervation, has been implicated in the pathogenesis of both PDD and DLB. Here we leverage the temporal resolution of magnetoencephalography with the spatial resolution of MRI tractography to explore the intersection of functional and structural connectivity of the NBM in a unique cohort of PDD and DLB patients undergoing deep brain stimulation of this structure. We observe that NBM-cortical structural and functional connectivity correlate within spatially and spectrally segregated networks including: (i) a beta band network to supplementary motor area, where activity in this region was found to drive activity in the NBM; (ii) a delta/theta band network to medial temporal lobe structures encompassing the parahippocampal gyrus; and (iii) a delta/theta band network to visual areas including lingual gyrus. These findings reveal functional networks of the NBM that are likely to subserve important roles in motor control, memory and visual function, respectively. Furthermore, they motivate future studies aimed at disentangling network contribution to disease phenotype.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- coherence
- DBS
- DTI
- MEG
- oscillations
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Brain
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- Av författaren/redakt...
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Oswal, Ashwini
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Gratwicke, James
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Akram, Harith
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Jahanshahi, Marj ...
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Zaborszky, Laszl ...
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Brown, Peter
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visa fler...
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Hariz, Marwan
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Zrinzo, Ludvic
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Foltynie, Tom
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Litvak, Vladimir
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Brain
- Av lärosätet
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Umeå universitet