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Posture-dependent c...
Posture-dependent collapse of the optic nerve subarachnoid space : A combined MRI and modeling study
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- Holmlund, Petter, 1988- (författare)
- Umeå universitet,Radiofysik
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- Stoverud, Karen-Helene (författare)
- Umeå universitet,Radiofysik
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- Wåhlin, Anders (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Radiofysik
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- Wiklund, Urban (författare)
- Umeå universitet,Radiofysik
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- Malm, Jan, Professor, 1957- (författare)
- Umeå universitet,Neurovetenskaper
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- Jóhannesson, Gauti, 1979- (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Oftalmiatrik
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- Eklund, Anders, 1965- (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Radiofysik
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(creator_code:org_t)
- Association for Research in Vision and Ophthalmology, 2021
- 2021
- Engelska.
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Ingår i: Investigative Ophthalmology and Visual Science. - : Association for Research in Vision and Ophthalmology. - 0146-0404 .- 1552-5783. ; 62:4
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PURPOSE: We hypothesize that a collapse of the optic nerve subarachnoid space (ONSAS) in the upright posture may protect the eyes from large translamina cribrosa pressure differences (TLCPD) believed to play a role in various optic nerve diseases (e.g., glaucoma). In this study, we combined magnetic resonance imaging (MRI) and mathematical modeling to investigate this potential ONSAS collapse and its effects on the TLCPD.METHODS: First, we performed MRI on six healthy volunteers in 6° head-down tilt (HDT) and 13° head-up tilt (HUT) to assess changes in ONSAS volume (measured from the eye to the optic canal) with changes in posture. The volume change reflects optic nerve sheath (ONS) distensibility. Second, we used the MRI data and mathematical modeling to simulate ONSAS pressure and the potential ONSAS collapse in a 90° upright posture.RESULTS: The MRI showed a 33% decrease in ONSAS volume from the HDT to HUT (P < 0.001). In the upright posture, the simulations predicted an ONSAS collapse 25 mm behind lamina cribrosa, disrupting the pressure communication between the ONSAS and the intracranial subarachnoid space. The collapse reduced the simulated postural increase in TLCPD by roughly 1 mm Hg, although this reduction was highly sensitive to ONS distensibility, varying between 0 and 4.8 mm Hg when varying the distensibility by ± 1 SD.CONCLUSIONS: The ONSAS volume along the optic nerve is posture dependent. The simulations supported the hypothesized ONSAS collapse in the upright posture and showed that even small changes in ONS stiffness/distensibility may affect the TLCPD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- Glaucoma
- Glymphatics
- Optic nerve subarachnoid space
- Posture
- Translaminar pressure
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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