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MAP2K1-Mutated Mela...
MAP2K1-Mutated Melanocytic Neoplasms With a SPARK-Like Morphology
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- Donati, Michele (författare)
- Department of Pathology, University Hospital Campus Bio-Medico, Rome, Italy; Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic
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- Nosek, Daniel (författare)
- Umeå universitet,Patologi
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- Waldenbäck, Pia (författare)
- Umeå universitet,Patologi
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- Martinek, Petr (författare)
- Bioptical Laboratory, Pilsen, Czech Republic
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- Jonsson, Björn-Anders (författare)
- Umeå universitet,Patologi
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- Galgonkova, Petra (författare)
- Department of Pathology, Regional Hospital, Czech Republic
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- Hawawrehova, Marcela (författare)
- Department of Pathology, NEMOS Hospital, Sokolov, Czech Republic
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- Berouskova, Petra (författare)
- Department of Pathology, Regional Hospital, Kladno, Czech Republic; and
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- Kastnerova, Liubov (författare)
- Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; Bioptical Laboratory, Pilsen, Czech Republic
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- Persichetti, Paolo (författare)
- Department of Pathology, Regional Hospital, Kladno, Czech Republic; and
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- Crescenzi, Anna (författare)
- Department of Pathology, University Hospital Campus Bio-Medico, Rome, Italy
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- Michal, Michal (författare)
- Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; Bioptical Laboratory, Pilsen, Czech Republic
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- Kazakov, Dmitry V. (författare)
- Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; Bioptical Laboratory, Pilsen, Czech Republic
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(creator_code:org_t)
- Wolters Kluwer, 2021
- 2021
- Engelska.
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Ingår i: American journal of dermatopathology. - : Wolters Kluwer. - 0193-1091 .- 1533-0311. ; 43:6, s. 412-417
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Specific alterations involving MAPK genes (MAP3K8 fusions, MAP3K3 fusions) have been recently detected in a subgroup of spitzoid neoplasms that seem to constitute a distinctive clinicopathologic group, occur mostly in younger patients (median age 18 years) and present with atypical histologic features associated with frequent homozygous deletion of CDKN2A, qualifying a high proportion of them as Spitz melanoma (malignant Spitz tumor). Apart from lesions with spitzoid morphology harboring MAP3K8 or MAP3K3 fusion, a single case with MAP2K1 deletion has been identified. The authors report herein 4 melanocytic lesions with a MAP2K1 mutation, all showing similar microscopic appearances, including spitzoid cytology and dysplastic architectural features, resembling so-called SPARK nevus, suggesting that these lesions may represent another distinctive group.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Donati, Michele
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Nosek, Daniel
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Waldenbäck, Pia
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Martinek, Petr
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Jonsson, Björn-A ...
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Galgonkova, Petr ...
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visa fler...
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Hawawrehova, Mar ...
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Berouskova, Petr ...
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Kastnerova, Liub ...
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Persichetti, Pao ...
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Crescenzi, Anna
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Michal, Michal
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Kazakov, Dmitry ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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American journal ...
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Umeå universitet