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Perspectives for sy...
Perspectives for systems biology in the management of tuberculosis
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- Kontsevaya, Irina (författare)
- Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
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- Lange, Christoph (författare)
- Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
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- Comella-Del-Barrio, Patricia (författare)
- Research Institute Germans Trias i Pujol, CIBER Respiratory Diseases, Universitat Autònoma de Barcelona, Badalona, Spain
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- Coarfa, Cristian (författare)
- Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States; Molecular and Cellular Biology, Center for Precision Environmental health, Baylor College of Medicine, TX, Houston, United States
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- DiNardo, Andrew R. (författare)
- Global Tuberculosis Program, Texas Children's Hospital, Dept of Pediatrics, Baylor College of Medicine, TX, Houston, United States
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- Gillespie, Stephen H. (författare)
- School of Medicine, University of St Andrew, St Andrews, United Kingdom
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- Hauptmann, Matthias (författare)
- Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany
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- Leschczyk, Christoph (författare)
- Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany
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- Mandalakas, Anna M. (författare)
- Global Tuberculosis Program, Texas Children's Hospital, Dept of Pediatrics, Baylor College of Medicine, TX, Houston, United States
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- Martinecz, Antal (författare)
- Dept of Biology, Pennsylvania State University, University Park, United States; Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, United States; Dept of Pharmacy, Faculty of Health Sciences, UiT, Arctic University of Norway, Tromsø, Norway
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- Merker, Matthias (författare)
- Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany
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- Niemann, Stefan (författare)
- Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany
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- Reimann, Maja (författare)
- Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
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- Rzhepishevska, Olena I (författare)
- Umeå universitet,Kemiska institutionen,Institutionen för klinisk mikrobiologi
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- Schaible, Ulrich E. (författare)
- Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany
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- Scheu, Katrin M. (författare)
- Research Center Borstel, Borstel, Germany
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- Schurr, Erwin (författare)
- Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Canada
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- Abel Zur Wiesch, Pia (författare)
- Dept of Biology, Pennsylvania State University, University Park, United States; Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, United States
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- Heyckendorf, Jan (författare)
- Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
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(creator_code:org_t)
- 2021-05-25
- 2021
- Engelska.
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Ingår i: European Respiratory Review. - : European Respiratory Society (ERS). - 0905-9180 .- 1600-0617. ; 30:160
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://err.ersjourn...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Standardised management of tuberculosis may soon be replaced by individualised, precision medicine-guided therapies informed with knowledge provided by the field of systems biology. Systems biology is a rapidly expanding field of computational and mathematical analysis and modelling of complex biological systems that can provide insights into mechanisms underlying tuberculosis, identify novel biomarkers, and help to optimise prevention, diagnosis and treatment of disease. These advances are critically important in the context of the evolving epidemic of drug-resistant tuberculosis. Here, we review the available evidence on the role of systems biology approaches - human and mycobacterial genomics and transcriptomics, proteomics, lipidomics/metabolomics, immunophenotyping, systems pharmacology and gut microbiomes - in the management of tuberculosis including prediction of risk for disease progression, severity of mycobacterial virulence and drug resistance, adverse events, comorbidities, response to therapy and treatment outcomes. Application of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach demonstrated that at present most of the studies provide "very low" certainty of evidence for answering clinically relevant questions. Further studies in large prospective cohorts of patients, including randomised clinical trials, are necessary to assess the applicability of the findings in tuberculosis prevention and more efficient clinical management of patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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Kontsevaya, Irin ...
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Lange, Christoph
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Comella-Del-Barr ...
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Coarfa, Cristian
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DiNardo, Andrew ...
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Gillespie, Steph ...
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Hauptmann, Matth ...
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Leschczyk, Chris ...
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Mandalakas, Anna ...
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Martinecz, Antal
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Merker, Matthias
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Niemann, Stefan
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Reimann, Maja
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Rzhepishevska, O ...
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Schaible, Ulrich ...
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Scheu, Katrin M.
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Schurr, Erwin
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Abel Zur Wiesch, ...
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Heyckendorf, Jan
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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European Respira ...
- Av lärosätet
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Umeå universitet