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Disparities in clin...
Disparities in clinical features and outcomes of peripartum cardiomyopathy in high versus low prevalent regions in Nigeria
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- Karaye, Kamilu M. (författare)
- Umeå universitet,Avdelningen för medicin,Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria; Department of Medicine, Bayero University, Kano, Nigeria; Hatter Institute for Cardiovascular Research in Africa & CHI, Cape Town, South Africa
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- Ishaq, Naser A. (författare)
- Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria
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- Sai'du, Hadiza (författare)
- Department of Medicine, Bayero University, Kano, Nigeria; Department of Medicine, Murtala Mohammed Specialist Hospital, Kano, Nigeria
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- Balarabe, Sulaiman A. (författare)
- Department of Medicine, Muhammad Abdullahi Wase Specialist Hospital, Kano, Nigeria
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- Ahmed, Bashir G. (författare)
- Department of Medicine, Muhammad Abdullahi Wase Specialist Hospital, Kano, Nigeria
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- Adamu, Umar G. (författare)
- Department of Medicine, Federal Medical Centre, Bidda, Nigeria & Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa
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- Mohammed, Idris Y. (författare)
- Department of Chemical Pathology, Aminu Kano Teaching Hospital, Medicine Bayero University, Kano, Nigeria
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- Oboirien, Isa (författare)
- Department of Medicine, Dalhatu Araf Specialist Hospital, Lafia, Nigeria
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- Umuerri, Ejiroghene M. (författare)
- Department of Medicine, Delta State University Teaching Hospital, Oghara, Nigeria
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- Mankwe, Abaram C. (författare)
- Department of Medicine, Federal medical centre, Yenagoa, Yenagoa, Nigeria
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- Shidali, Vincent Y. (författare)
- Department of Medicine, Federal Medical Center, Keffi, Nigeria
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- Dodiyi-Manuel, Sotonye (författare)
- Department of Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
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- Njoku, Paschal (författare)
- University of Nigeria Teaching Hospital, Enugu, Nigeria
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- Olunuga, Taiwo (författare)
- Department of Medicine, Federal Medical centre, Abeokuta, Nigeria
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- Josephs, Veronica (författare)
- Department of Medicine, University of Benin Teaching Hospital, Benin, Nigeria
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- Mbakwem, Amam C. (författare)
- Department of Medicine, University of Lagos, Lagos, Nigeria
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- Ogah, Okechukwu S. (författare)
- Department of Medicine, University College Hospital, Ibadan, Nigeria
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- Tukur, Jamilu (författare)
- Department of Obstetrics and Gynecology, Bayero University, Kano, Nigeria
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- Okeahialam, Basil (författare)
- Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria
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- Stewart, Simon (författare)
- Torrens University Australia, SA, Adelaide, Australia
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- Henein, Michael (författare)
- Umeå universitet,Avdelningen för medicin
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- Sliwa, Karen (författare)
- Hatter Institute for Cardiovascular Research in Africa & CHI, Cape Town, South Africa
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(creator_code:org_t)
- 2021-06-17
- 2021
- Engelska.
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Ingår i: ESC Heart Failure. - : John Wiley & Sons. - 2055-5822. ; 8:4, s. 3257-3267
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Aims: The prospective, multicentre Peripartum Cardiomyopathy in Nigeria (PEACE) registry originally demonstrated a high prevalence of peripartum cardiomyopathy (PPCM) among patients originating from Kano, North-West Nigeria. In a post hoc analysis, we sought to determine if this phenomenon was characterized by a differential case profile and outcome among PPCM cases originating elsewhere.Methods and results: Overall, 199 (81.6%) of a total 244 PPCM patients were recruited from three sites in Kano, compared with 45 patients (18.4%) from 11 widely dispersed centres across Nigeria. Presence and extent of ventricular myocardial remodelling during follow-up, relative to baseline status, were assessed by echocardiography. During median 17 months follow-up, Kano patients demonstrated significantly better myocardial reverse remodelling than patients from other sites. Overall, 50.6% of patients from Kano versus 28.6% from other regions were asymptomatic (P = 0.029) at study completion, with an accompanying difference in all-cause mortality (17.6% vs. 22.2% respectively, P = 0.523) not reaching statistical significance. Alternatively, 135/191 (84.9%) of Kano patients had selenium deficiency (<70 μg/L), and 46/135 (34.1%) of them received oral selenium supplementation. Critically, those that received selenium supplementation demonstrated better survival (6.5% vs. 21.2%; P = 0.025), but the supplement did not have significant impact on myocardial remodelling.Conclusions: This study has shown important non-racial regional disparities in the clinical features and outcomes of PPCM patients in Nigeria, that might partly be explained by selenium supplementation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Outcomes
- PEACE registry
- Peripartum cardiomyopathy
- Regional disparities
- Selenium
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Karaye, Kamilu M ...
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Ishaq, Naser A.
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Sai'du, Hadiza
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Balarabe, Sulaim ...
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Ahmed, Bashir G.
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Adamu, Umar G.
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visa fler...
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Mohammed, Idris ...
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Oboirien, Isa
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Umuerri, Ejirogh ...
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Mankwe, Abaram C ...
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Shidali, Vincent ...
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Dodiyi-Manuel, S ...
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Njoku, Paschal
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Olunuga, Taiwo
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Josephs, Veronic ...
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Mbakwem, Amam C.
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Ogah, Okechukwu ...
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Tukur, Jamilu
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Okeahialam, Basi ...
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Stewart, Simon
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Henein, Michael
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Sliwa, Karen
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Umeå universitet