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Mild impairment of ...
Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women
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- Söderström, Elisabet (författare)
- Umeå universitet,Klinisk kemi
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- Blind, Ravna (författare)
- Umeå universitet,Klinisk kemi
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- Wennberg, Patrik, 1972- (författare)
- Umeå universitet,Allmänmedicin
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- Andersson, Jonas, 1977- (författare)
- Umeå universitet,Avdelningen för medicin,Skellefteå Research Unit
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- Söderberg, Stefan (författare)
- Umeå universitet,Kardiologi,Avdelningen för medicin
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- Nilsson, Torbjörn K. (författare)
- Umeå universitet,Klinisk kemi
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- Hultdin, Johan (författare)
- Umeå universitet,Klinisk kemi
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(creator_code:org_t)
- 2021-07-08
- 2021
- Engelska.
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Ingår i: Scandinavian Journal of Clinical and Laboratory Investigation. - : Taylor & Francis Group. - 0036-5513 .- 1502-7686. ; 81:6, s. 438-445
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.tandfonl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Impaired renal function is associated both with the development of cardiovascular disease and its prognosis. A new syndrome called ' Shrunken Pore Syndrome ' has been suggested, as the estimated glomerular filtration rate for cystatin C (eGFR(cystatin C)) is affected earlier due to differences in molecular size compared to eGFR(creatinine). The aim was to investigate if a lower eGFR(cystatin C)/eGFR(creatinine) ratio in a prospective setting increases the risk of later developing a first-ever myocardial infarction (MI) independently of other cardiovascular risk factors. We used a nested case-referent study design within the Northern Sweden Health and Disease Study, and 545 subjects (29.0% women) were identified who prospectively developed a first-ever MI, and their 1054 matched referents. For women, but not for men, one standard deviation (SD) increase of ln z-scores of eGFR(cystatin C)/eGFR(creatinine) ratio was associated with a lower risk of a future MI: odds ratio [95% confidence interval] 0.58 [0.34-0.99], adjusted for apolipoprotein B/A1 ratio, CRP, homocysteine, systolic blood pressure, body mass index, and diabetes. Furthermore, a high eGFR(creatinine) associated independently with an increased risk of future MI in men only: OR 1.25 [1.05-1.48]. Thus, for women, a lower eGFR(cystatin C)/eGFR(creatinine) ratio is associated with a higher risk of having a future first-ever MI, and it may be a valuable, easily implemented biomarker for risk of cardiovascular disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Myocardial infarction
- creatinine
- cystatin C
- glomerular filtration rate
- chronic renal insufficiency
- shrunken pore syndrome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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