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Self-injurious beha...
Self-injurious behaviour in patients with bipolar disorder and attention deficit hyperactivity disorder after central stimulant start : a retrospective study based on the lisie cohort
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- Öhlund, Louise (författare)
- Umeå universitet,Psykiatri,Sunderby Research Unit
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- Ott, Michael (författare)
- Umeå universitet,Avdelningen för medicin
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- Lundqvist, Robert (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Sunderby Research Unit
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- Sandlund, Mikael (författare)
- Umeå universitet,Psykiatri
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- Salander Renberg, Ellinor (författare)
- Umeå universitet,Psykiatri
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- Werneke, Ursula (författare)
- Umeå universitet,Psykiatri,Sunderby Research Unit
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(creator_code:org_t)
- 2021-08-13
- 2021
- Engelska.
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Ingår i: European psychiatry. - : Cambridge University Press. - 0924-9338 .- 1778-3585. ; 64:S1, s. S79-S80
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Currently, our understanding remains limited of how co-occurring bipolar disorder and attention deficit hyperactivity disorder (ADHD) should be treated.ObjectivesTo evaluate the impact of central stimulant treatment on self-injurious behaviour in patients with a dual diagnosis of bipolar disorder or schizoaffective disorder and ADHD.MethodsRetrospective cohort study (LiSIE) into effects and side-effects of lithium as compared to other mood stabilisers. Here, using a mirror-image design, we compared suicide attempts and non-suicidal self-injury events within 6 months and 2 years before and after central stimulant treatment start.ResultsOf 1564 eligible patients, 206 patients met inclusion criteria; having a dual diagnosis of bipolar disorder or schizoaffective disorder and ADHD at first central stimulant initiation. In these, suicide attempts and non-suicidal self-injury events decreased significantly within both 6 months (p = 0.004) and 2 years (p = 0.028) after central stimulant start. After multiple adjustments, this effect was preserved 2 years after central stimulant start (OR 0.63, 95% CI; 0.40 – 0.98, p = 0.041).ConclusionsCentral stimulant treatment may reduce the risk of self-injurious behavior in patients with a dual diagnosis of bipolar disorder or schizoaffective disorder and ADHD. However, to reduce the risk of manic switches, concomitant mood stabilising treatment remains warranted.DisclosureMichael Ott has been a scientific advisory board member of Astra Zeneca Sweden, Ursula Werneke has received funding for educational activities on behalf of Norrbotten Region (Masterclass Psychiatry Programme 2014–2018 and EAPM 2016, Luleå, Sweden): Astra
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- attention deficit disorder with hyperactivity
- central nervous system stimulants
- self-injurious behaviour
- bipolar disorder
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