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Sökning: id:"swepub:oai:DiVA.org:umu-190114" > Natriuretic Peptide...

Natriuretic Peptides and Risk of Type 2 Diabetes : Results From the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium

Sujana, Chaterina (författare)
Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute for Medical Information Processing, Biometry, Epidemiology (IBE), Pettenkofer School of Public Health, Ludwig-Maximilians-Universität, Munich, Germany; German Center for Diabetes Research (DZD), Partner Munich-Neuherberg, Germany
Salomaa, Veikko (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
Kee, Frank (författare)
Centre for Public Health, Queens University of Belfast, Northern Ireland, Belfast, United Kingdom
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Costanzo, Simona (författare)
Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy
Söderberg, Stefan (författare)
Umeå universitet,Avdelningen för medicin
Jordan, Jens (författare)
Institute of Aerospace Medicine, German Aerospace Center (DLR) and University of Cologne, Cologne, Germany
Jousilahti, Pekka (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
Neville, Charlotte (författare)
Centre for Public Health, Queens University of Belfast, Northern Ireland, Belfast, United Kingdom
Iacoviello, Licia (författare)
Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy; Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
Oskarsson, Viktor (författare)
Umeå universitet,Avdelningen för medicin
Westermann, Dirk (författare)
Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
Koenig, Wolfgang (författare)
Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Munich, Germany
Kuulasmaa, Kari (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
Reinikainen, Jaakko (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
Blankenberg, Stefan (författare)
Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Hamburg, Lübeck, Kiel, Hamburg, Germany
Zeller, Tanja (författare)
Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Hamburg, Lübeck, Kiel, Hamburg, Germany
Herder, Christian (författare)
Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; Division of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD), Partner Düsseldorf, Germany
Mansmann, Ulrich (författare)
Institute for Medical Information Processing, Biometry, Epidemiology (IBE), Pettenkofer School of Public Health, Ludwig-Maximilians-Universität, Munich, Germany
Peters, Annette (författare)
Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Partner Munich-Neuherberg, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Munich, Germany
Thorand, Barbara (författare)
Institute of Epidemiology, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Partner Munich-Neuherberg, Munich-Neuherberg, Germany
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 (creator_code:org_t)
2021-09-14
2021
Engelska.
Ingår i: Diabetes Care. - : American Diabetes Association (ADA). - 0149-5992 .- 1935-5548. ; 44:11, s. 2527-2535
Relaterad länk:
https://diabetesjour...
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https://urn.kb.se/re...
https://doi.org/10.2...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVE: Natriuretic peptide (NP) concentrations are increased in cardiovascular diseases (CVDs) but are associated with a lower diabetes risk. We investigated associations of N-terminal pro-B-type NP (NT-proBNP) and midregional proatrial NP (MR-proANP) with incident type 2 diabetes stratified by the presence of CVD.RESEARCH DESIGN AND METHODS: Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium, we included 45,477 participants with NT-proBNP measurements (1,707 developed type 2 diabetes over 6.5 years of median follow-up; among these, 209 had CVD at baseline) and 11,537 participants with MR-proANP measurements (857 developed type 2 diabetes over 13.8 years of median follow-up; among these, 106 had CVD at baseline). The associations were estimated using multivariable Cox regression models.RESULTS: Both NPs were inversely associated with incident type 2 diabetes (hazard ratios [95% CI] per 1-SD increase of log NP: 0.84 [0.79; 0.89] for NT-proBNP and 0.77 [0.71; 0.83] for MR-proANP). The inverse association between NT-proBNP and type 2 diabetes was significant in individuals without CVD but not in individuals with CVD (0.81 [0.76; 0.86] vs. 1.04 [0.90; 1.19]; P multiplicative interaction = 0.001). There was no significant difference in the association of MR-proANP with type 2 diabetes between individuals without and with CVD (0.75 [0.69; 0.82] vs. 0.81 [0.66; 0.99]; P multiplicative interaction = 0.236).CONCLUSIONS: NT-proBNP and MR-proANP are inversely associated with incident type 2 diabetes. However, the inverse association of NT-proBNP seems to be modified by the presence of CVD. Further investigations are warranted to confirm our findings and to investigate the underlying mechanisms.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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