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Convalescence plasm...
Convalescence plasma treatment of COVID-19 : results from a prematurely terminated randomized controlled open-label study in Southern Sweden
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- Holm, Karin (författare)
- Department of Infectious diseases, Skåne University Hospital, Lund, Sweden
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- Lundgren, Maria N (författare)
- Department of Clinical Immunology and Transfusion Medicine, University and Regional Laboratories, Region Skåne, Sweden
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- Kjeldsen-Kragh, Jens (författare)
- Department of Clinical Immunology and Transfusion Medicine, University and Regional Laboratories, Region Skåne, Sweden
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- Ljungquist, Oskar (författare)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Böttiger, Blenda (författare)
- Department of Clinical Microbiology, University and Regional Laboratories, Region Skåne, Sweden
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- Wikén, Christian (författare)
- Department of Infectious diseases, Skåne University Hospital, Lund, Sweden
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- Öberg, Jonas (författare)
- Department of Infectious diseases, Skåne University Hospital, Lund, Sweden
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- Fernström, Nils (författare)
- Department of Infectious diseases, Skåne University Hospital, Lund, Sweden
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- Rosendal, Ebba (författare)
- Umeå University,Umeå universitet,Institutionen för klinisk mikrobiologi
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- Överby, Anna K. (författare)
- Umeå University,Umeå universitet,Institutionen för klinisk mikrobiologi
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- Wigren, Julia (författare)
- Umeå University,Umeå universitet,Institutionen för klinisk mikrobiologi
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- Forsell, Mattias (författare)
- Umeå University,Umeå universitet,Institutionen för klinisk mikrobiologi
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- Landin-Olsson, Mona (författare)
- Department of Endocrinology, Skåne University Hospital, Lund, Sweden
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- Rasmussen, Magnus (författare)
- Department of Infectious diseases, Skåne University Hospital, Lund, Sweden
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(creator_code:org_t)
- 2021-12-04
- 2021
- Engelska.
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Ingår i: BMC Research Notes. - : BioMed Central. - 1756-0500. ; 14:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://bmcresnotes....
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objective: Convalescent plasma has been tried as therapy for various viral infections. Early observational studies of convalescent plasma treatment for hospitalized COVID-19 patients were promising, but randomized controlled studies were lacking at the time. The objective of this study was to investigate if convalescent plasma is beneficial to hospitalized patients with COVID-19.Results: Hospitalized patients with confirmed COVID-19 and an oxygen saturation below 94% were randomized 1:1 to receive convalescent plasma in addition to standard of care or standard of care only. The primary outcome was number of days of oxygen treatment to keep saturation above 93% within 28 days from inclusion. The study was prematurely terminated when thirty-one of 100 intended patients had been included. The median time of oxygen treatment among survivors was 11 days (IQR 6–15) for the convalescent plasma group and 7 days (IQR 5–9) for the standard of care group (p = 0.4, median difference -4). Two patients in the convalescent plasma group and three patients in the standard of care group died (p = 0.64, OR 0.49, 95% CI 0.08–2.79). Thus no significant differences were observed between the groups.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Convalescent plasma
- COVID-19
- Desaturation
- Oxygen therapy
- SARS-CoV2
- Infectious Diseases
- infektionssjukdomar
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Holm, Karin
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Lundgren, Maria ...
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Kjeldsen-Kragh, ...
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Ljungquist, Oska ...
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Böttiger, Blenda
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Wikén, Christian
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visa fler...
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Öberg, Jonas
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Fernström, Nils
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Rosendal, Ebba
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Överby, Anna K.
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Wigren, Julia
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Forsell, Mattias
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Landin-Olsson, M ...
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Rasmussen, Magnu ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Anestesi och int ...
- Artiklar i publikationen
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BMC Research Not ...
- Av lärosätet
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Umeå universitet
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Lunds universitet