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Calf Muscle Oxygena...
Calf Muscle Oxygenation is Impaired and May Decline with Age in Young Patients with Total Cavopulmonary Connection
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- Sthen Bergdahl, Magne (författare)
- Umeå universitet,Pediatrik,Centre for Pediatrics and Adolescent Medicine, Norrlands University Hospital, Umeå, Sweden
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- Crenshaw, Albert G. (författare)
- Högskolan i Gävle,Arbetshälsovetenskap,Centrum för belastningsskadeforskning
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- Rylander Hedlund, Eva (författare)
- Department of Women’s and Children’s Health, Division of Pediatric Cardiology, Karolinska Institutet, Stockholm, Sweden
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- Sjöberg, Gunnar (författare)
- Karolinska Institutet
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- Rydberg, Annika (författare)
- Umeå universitet,Pediatrik,Umeå University
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- Sandberg, Camilla (författare)
- Umeå universitet,Avdelningen för fysioterapi,Avdelningen för medicin,Umeå University
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(creator_code:org_t)
- 2021-10-08
- 2022
- Engelska.
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Ingår i: Pediatric Cardiology. - : Springer. - 0172-0643 .- 1432-1971. ; 43:2, s. 449-456
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Patients palliated with Total Cavopulmonary Connection have a lower muscle mass and a lower exercise capacity. We assessed calf muscle oxidative metabolism during and after heel raise exercise to exhaustion in young patients with TCPC compared to healthy peers. Near-infrared spectroscopy was used for measuring oxygen metabolism in the medial portion of the gastrocnemius muscle. Forty-three patients with TCPC, aged 6–18 years, were compared with 43 age and sex-matched healthy control subjects. Subgroups were formed to include children (6–12 years) and adolescents (13–18 years) to determine if these age groups influenced the results. During exercise, for the patients compared to controls there was a lower increase in deoxygenated hemoglobin (oxygen extraction) (5.13 ± 2.99au vs. 7.75 ± 4.15au, p = 0.001) and a slower rate of change in total hemoglobin (blood volume) (0.004 ± 0.015au vs 0.016 ± 0.01au, p = 0.001). Following exercise, patients exhibited a slower initial increase in tissue oxygenation saturation index (0.144 ± 0.11au vs 0.249 ± 0.226au, p = 0.007) and a longer half-time to maximum hyperemia (23.7 ± 11.4 s vs 16.8 ± 7.5 s, p = 0.001). On the subgroup level, the adolescents differed compared to healthy peers, whereas the children did not. Young patients with TCPC had impaired oxidative metabolism during exercise and required a longer time to recover. In that the differences were seen in the adolescent group and not in the children group may indicate a declining function with age.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- Exercise
- Fontan
- Near-infrared spectroscopy
- NIRS
- TCPC
- Total cavopulmonary connection
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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