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Circulating Sex Hor...
Circulating Sex Hormone Levels and Colon Cancer Risk in Men : A Nested Case–Control Study and Meta-Analysis
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- Harbs, Justin (författare)
- Umeå universitet,Onkologi
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- Rinaldi, Sabina (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Gicquiau, Audrey (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Keski-Rahkonen, Pekka (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Mori, Nagisa (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Liu, Xijia (författare)
- Umeå universitet,Statistik
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- Kaaks, Rudolf (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Katzke, Verena (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Schulze, Matthias B. (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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- Agnoli, Claudia (författare)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
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- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy
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- Bueno-De-Mesquita, Bas (författare)
- Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
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- Crous-Bou, Marta (författare)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Sánchez, Maria-Jose (författare)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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- Aizpurua, Amaia (författare)
- Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain
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- Chirlaque, María-Dolores (författare)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain
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- Gurrea, Aurelio Barricarte (författare)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
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- Travis, Ruth C. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Watts, Eleanor L. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Christakoudi, Sofia (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, Faculty of Life Sciences & Medicine, King’s College London, London, United Kingdom
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- Tsilidis, Konstantinos K. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, Faculty of Medicine, University of Ioannina School of Medicine, Ioannina, Greece
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Murphy, Neil (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Harlid, Sophia, 1978- (författare)
- Umeå universitet,Onkologi
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(creator_code:org_t)
- American Association for Cancer Research, 2022
- 2022
- Engelska.
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 31:4, s. 793-803
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Endogenous sex hormones may contribute to higher colorectal cancer incidence rates in men compared with women, but despite an increased number of studies, clear evidence is lacking.Methods: We conducted a comprehensive nested case–control study of circulating concentrations of sex hormones, sex hormone precursors, and sex hormone binding globulin (SHBG) in relation to subsequent colon cancer risk in European men. Concentrations were measured using liquid LC/MS-MS in prospectively collected plasma samples from 690 cases and 690 matched controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Multivariable conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). In addition, we conducted a meta-analysis of previous studies on men.Results: Circulating levels of testosterone (OR, 0.68; 95% CI, 0.51–0.89) and SHBG (OR, 0.77; 95% CI, 0.62–0.96) were inversely associated with colon cancer risk. For free testosterone, there was a nonsignificant inverse association (OR, 0.83; 95% CI, 0.58–1.18). In a dose–response meta-analysis of endogenous sex hormone levels, inverse associations with colorectal/colon cancer risk were found for testosterone [relative risks (RR) per 100 ng/dL ¼ 0.98; 95% CI, 0.96–1.00; I2 ¼ 22%] and free testosterone (RR per 1 ng/dL ¼ 0.98; 95% CI, 0.95–1.00; I2 ¼ 0%).Conclusions: Our results provide suggestive evidence for the association between testosterone, SHBG, and male colon cancer development.Impact: Additional support for the involvement of sex hormones in male colon cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Oncology
- onkologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Harbs, Justin
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Rinaldi, Sabina
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Gicquiau, Audrey
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Keski-Rahkonen, ...
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Mori, Nagisa
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Liu, Xijia
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visa fler...
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Kaaks, Rudolf
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Katzke, Verena
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Schulze, Matthia ...
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Agnoli, Claudia
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Tumino, Rosario
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Bueno-De-Mesquit ...
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Crous-Bou, Marta
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Sánchez, Maria-J ...
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Aizpurua, Amaia
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Chirlaque, María ...
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Gurrea, Aurelio ...
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Travis, Ruth C.
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Watts, Eleanor L ...
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Christakoudi, So ...
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Tsilidis, Konsta ...
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Weiderpass, Elis ...
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Gunter, Marc J.
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van Guelpen, Bet ...
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Murphy, Neil
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Harlid, Sophia, ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Cancer Epidemiol ...
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