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Comparative analysi...
Comparative analysis of the gut microbiota composition between knee osteoarthritis and Kashin-Beck disease in Northwest China
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- Ning, Yujie (författare)
- School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
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- Minhan, Hu (författare)
- School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
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- Yi, Gong (författare)
- School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
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- Ruitian, Huang (författare)
- School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
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- Ke, Xu (författare)
- Department of Joint Surgery, Hong Hui Hospital, Xi’an Jiaotong University, No.555, Xi’an, People’s Republic of China
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- Sijie, Chen (författare)
- School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
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- Feiyu, Zhang (författare)
- School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
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- Yanli, Liu (författare)
- School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
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- Feihong, Chen (författare)
- School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
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- Yanhai, Chang (författare)
- Shaanxi Provincial People’s Hospital, Xi’an, People’s Republic of China
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- Guanghui, Zhao (författare)
- Department of Joint Surgery, Hong Hui Hospital, Xi’an Jiaotong University, No.555, Xi’an, People’s Republic of China
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- Cheng, Li (författare)
- Shaanxi Institute of Endemic Disease Prevention and Control, Xi’an, People’s Republic of China
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- Rong, Zhou (författare)
- Shaanxi Institute of Endemic Disease Prevention and Control, Xi’an, People’s Republic of China
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- Lammi, Mikko, 1961- (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China,Chondrogeni and osteogenic differentiation
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- Xiong, Guo (författare)
- School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
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- Xi, Wang (författare)
- School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China; Department of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, People’s Republic of China; Global Health Institute, Xi’an Jiaotong University Health Science Center, Xi’an, People’s Republic of China
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School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China Department of Joint Surgery, Hong Hui Hospital, Xi’an Jiaotong University, No555, Xi’an, People’s Republic of China (creator_code:org_t)
- 2022-05-30
- 2022
- Engelska.
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Ingår i: Arthritis Research & Therapy. - : BioMed Central. - 1478-6362. ; 24:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure between OA and KBD patients.Methods: Fecal samples collected from OA and KBD patients were used to characterize the gut microbiota using 16S rDNA gene sequencing. To identify whether gut microbial changes at the species level are associated with the genes or functions of the gut bacteria between OA and KBD groups, metagenomic sequencing of fecal samples from OA and KBD subjects was performed.Results: The OA group was characterized by elevated Epsilonbacteraeota and Firmicutes levels. A total of 52 genera were identified to be significantly differentially abundant between the two groups. The genera Raoultella, Citrobacter, Flavonifractor, g__Lachnospiraceae_UCG-004, and Burkholderia-Caballeronia-Paraburkholderia were more abundant in the OA group. The KBD group was characterized by higher Prevotella_9, Lactobacillus, Coprococcus_2, Senegalimassilia, and Holdemanella. The metagenomic sequencing showed that the Subdoligranulum_sp._APC924/74, Streptococcus_parasanguinis, and Streptococcus_salivarius were significantly increased in abundance in the OA group compared to those in the KBD group, and the species Prevotella_copri, Prevotella_sp._CAG:386, and Prevotella_stercorea were significantly decreased in abundance in the OA group compared to those in the KBD group by using metagenomic sequencing.Conclusion: Our study provides a comprehensive landscape of the gut microbiota between OA and KBD patients and provides clues for better understanding the mechanisms underlying the pathogenesis of OA and KBD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Osteoarthritis
- Kashin-Beck disease
- 16S sequencing
- Metagenomic sequencing
- Microbiota
- mikrobiologi
- Microbiology
- molecular biotechnology (dept of cell- and molecular biology)
- molekylär bioteknik (inst f cell- o molekylärbiologi)
- reumatologi
- rheumatology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ning, Yujie
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Minhan, Hu
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Yi, Gong
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Ruitian, Huang
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Ke, Xu
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Sijie, Chen
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visa fler...
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Feiyu, Zhang
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Yanli, Liu
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Feihong, Chen
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Yanhai, Chang
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Guanghui, Zhao
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Cheng, Li
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Rong, Zhou
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Lammi, Mikko, 19 ...
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Xiong, Guo
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Xi, Wang
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Arthritis Resear ...
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Umeå universitet