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Current and novel t...
Current and novel treatment options for obstructive sleep apnoea
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- Randerath, Winfried (författare)
- Bethanien Hospital, Clinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Institute of Pneumology at the University of Cologne, Solingen, Germany
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- de Lange, Jan (författare)
- Dept of Oral and Maxillofacial Surgery, Amsterdam UMC and Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam, Amsterdam, Netherlands
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- Hedner, Jan (författare)
- Sahlgrenska University Hospital, Gothenburg, Sweden
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- Ho, Jean Pierre T. F. (författare)
- Dept of Oral and Maxillofacial Surgery, Amsterdam UMC and Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam, Amsterdam, Netherlands
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- Marklund, Marie E. (författare)
- Umeå universitet,Institutionen för odontologi
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- Schiza, Sofia (författare)
- Sleep Disorders Unit, Dept of Respiratory Medicine, Medical School, University of Crete, Heraklion, Greece
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- Steier, Jörg (författare)
- Lane Fox Unit and Sleep Disorders Centre at Guy’s & St Thomas’ NHS Foundation Trust, Centre for Human & Applied Physiological Sciences, King’s College London, London, United Kingdom
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- Verbraecken, Johan (författare)
- Antwerp University Hospital and University of Antwerp, Edegem, Belgium
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(creator_code:org_t)
- 2022-05-19
- 2022
- Engelska.
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Ingår i: ERJ Open Research. - : European Respiratory Society. - 2312-0541. ; 8:2
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Obstructive sleep apnoea is a challenging medical problem due to its prevalence, its impact on quality of life and performance in school and professionally, the implications for risk of accidents, and comorbidities and mortality. Current research has carved out a broad spectrum of clinical phenotypes and defined major pathophysiological components. These findings point to the concept of personalised therapy, oriented on both the distinct clinical presentation and the most relevant pathophysiology in the individual patient. This leads to questions of whether sufficient therapeutic options other than positive airway pressure (PAP) alone are available, for which patients they may be useful, if there are specific indications for single or combined treatment, and whether there is solid scientific evidence for recommendations. This review describes our knowledge on PAP and non-PAP therapies to address upper airway collapsibility, muscle responsiveness, arousability and respiratory drive. The spectrum is broad and heterogeneous, including technical and pharmaceutical options already in clinical use or at an advanced experimental stage. Although there is an obvious need for more research on single or combined therapies, the available data demonstrate the variety of effective options, which should replace the unidirectional focus on PAP therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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