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Genome-wide interac...
Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk
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- Li, Yafang (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
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- Xiao, Xiangjun (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States
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- Li, Jianrong (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States
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- Byun, Jinyoung (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States
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- Cheng, Chao (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
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- Bossé, Yohan (författare)
- Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Canada
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- McKay, James (författare)
- Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Albanes, Demetrios (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States
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- Lam, Stephen (författare)
- Department of Integrative Oncology, University of British Columbia, Vancouver, Canada
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- Tardon, Adonina (författare)
- Public Health Department, University of Oviedo, Asturias, Spain
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- Chen, Chu (författare)
- Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
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- Bojesen, Stig E. (författare)
- Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2177, Denmark
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- Landi, Maria T. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States
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- Johansson, Mattias (författare)
- Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Risch, Angela (författare)
- Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany; University of Salzburg and Cancer Cluster Salzburg, Austria
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- Bickeböller, Heike (författare)
- Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Germany
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- Wichmann, H-Erich (författare)
- Institute of Medical Statistics and Epidemiology, Technical University Munich, Germany
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- Christiani, David C. (författare)
- Departments of Environmental Health and Epidemiology, Harvard TH Chan School of Public Health, Boston, United States
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- Rennert, Gad (författare)
- Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
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- Arnold, Susanne (författare)
- University of Kentucky, Markey Cancer Center, KY, Lexington, United States
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- Goodman, Gary (författare)
- Swedish Cancer Institute, Seattle, WA 98104, USA
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- Field, John K. (författare)
- Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
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- Davies, Michael P A (författare)
- Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
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- Shete, Sanjay S. (författare)
- Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center, Houston, United States; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, United States
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- Le Marchand, Loic (författare)
- Epidemiology Program, University of Hawaii Cancer Center, Honolulu, United States
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- Melander, O. (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Brunnström, H. (författare)
- Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Liu, Geoffrey (författare)
- University Health Network- The Princess Margaret Cancer Centre, Toronto, Canada
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- Hung, Rayjean J. (författare)
- Luenfeld-Tanenbaum Research Institute, Sinai Health System, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Canada
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- Andrew, Angeline S. (författare)
- Departments of Epidemiology and Community and Family Medicine, Dartmouth College, Hanover, United States
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- Kiemeney, Lambertus A. (författare)
- Radboud University Medical Center, Nijmegen, Netherlands
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- Shen, Hongbing (författare)
- Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China
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- Sun, Ryan (författare)
- Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center, Houston, United States
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- Zienolddiny, Shan (författare)
- National Institute of Occupational Health, Oslo, Norway
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- Grankvist, Kjell (författare)
- Umeå universitet,Klinisk kemi
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- Johansson, Mikael (författare)
- Umeå universitet,Onkologi
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- Caporaso, Neil (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States
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- Teare, Dawn M. (författare)
- Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
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- Hong, Yun-Chul (författare)
- Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
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- Lazarus, Philip (författare)
- Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States
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- Schabath, Matthew B. (författare)
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States
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- Aldrich, Melinda C. (författare)
- Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center Nashville, United States
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- Schwartz, Ann G. (författare)
- Department of Oncology, Wayne State University School of Medicine, Detroit, United States; Karmanos Cancer Institute, Detroit, United States
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- Gorlov, Ivan (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
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- Purrington, Kristen (författare)
- Karmanos Cancer Institute, Detroit, United States
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- Yang, Ping (författare)
- Division of Epidemiology, Department of Health Sciences Research, MN, United States
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- Liu, Yanhong (författare)
- Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
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- Han, Younghun (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States
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- Bailey-Wilson, Joan E. (författare)
- National Human Genome Research Institute, NIH, Baltimore, United States
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- Pinney, Susan M. (författare)
- University of Cincinnati College of Medicine, Cincinnati, United States
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- Mandal, Diptasri (författare)
- Louisiana State University Health Sciences Center, New Orleans, United States
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- Willey, James C. (författare)
- College of Medicine and Life Sciences, University of Toledo, Toledo, United States
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- Gaba, Colette (författare)
- University of Toledo College of Medicine, Toledo, United States
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- Brennan, Paul (författare)
- Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Amos, Christopher I. (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
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(creator_code:org_t)
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et al
- 2022-02-09
- 2022
- Engelska.
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 31:16, s. 2831-2843
- Relaterad länk:
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https://doi.org/10.1...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene-sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency < 0.05), rs17662871 [odds ratio (OR) = 0.71, P = 4.29×10-8); rs79942605 (OR = 2.17, P = 2.81×10-8) and rs208908 (OR = 0.70, P = 4.54×10-8) were identified with different risk effect of lung cancer between men and women. Further expression quantitative trait loci and functional annotation analysis suggested rs208908 affects lung cancer risk through differential regulation of Coxsackie virus and adenovirus receptor gene expression in lung tissues between men and women. Our study is one of the first studies to provide novel insights about the genetic and molecular basis for sex disparity in lung cancer development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- case control study
- female
- genetic predisposition
- genetics
- genome-wide association study
- human
- lung
- lung tumor
- male
- single nucleotide polymorphism
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Lung
- Lung Neoplasms
- Male
- Polymorphism, Single Nucleotide
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Li, Yafang
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Xiao, Xiangjun
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Li, Jianrong
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Byun, Jinyoung
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Cheng, Chao
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Bossé, Yohan
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visa fler...
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McKay, James
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Albanes, Demetri ...
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Lam, Stephen
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Tardon, Adonina
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Chen, Chu
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Bojesen, Stig E.
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Landi, Maria T.
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Johansson, Matti ...
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Risch, Angela
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Bickeböller, Hei ...
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Wichmann, H-Eric ...
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Christiani, Davi ...
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Rennert, Gad
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Arnold, Susanne
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Goodman, Gary
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Field, John K.
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Davies, Michael ...
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Shete, Sanjay S.
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Le Marchand, Loi ...
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Melander, O.
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Brunnström, H.
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Liu, Geoffrey
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Hung, Rayjean J.
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Andrew, Angeline ...
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Kiemeney, Lamber ...
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Shen, Hongbing
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Sun, Ryan
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Zienolddiny, Sha ...
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Grankvist, Kjell
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Johansson, Mikae ...
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Caporaso, Neil
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Teare, Dawn M.
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Hong, Yun-Chul
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Lazarus, Philip
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Schabath, Matthe ...
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Aldrich, Melinda ...
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Schwartz, Ann G.
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Gorlov, Ivan
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Purrington, Kris ...
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Yang, Ping
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Liu, Yanhong
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Han, Younghun
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Bailey-Wilson, J ...
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Pinney, Susan M.
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Mandal, Diptasri
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Willey, James C.
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Gaba, Colette
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Brennan, Paul
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Amos, Christophe ...
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Human Molecular ...
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Umeå universitet
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