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The effect of a con...
The effect of a conditional cash transfer on HIV incidence in young women in rural South Africa (HPTN 068) : a phase 3, randomised controlled trial
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- Pettifor, Audrey (författare)
- Department of Epidemiology, University of North Carolina, NC, Chapel Hill, United States; Carolina Population Center, University of North Carolina, NC, Chapel Hill, United States; Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa
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- MacPhail, Catherine (författare)
- Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa; School of Health, University of New England, NSW, Armidale, Australia
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- Hughes, James P (författare)
- Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
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- Selin, Amanda (författare)
- Carolina Population Center, University of North Carolina, NC, Chapel Hill, United States
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- Wang, Jing (författare)
- Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Gómez-Olivé, F Xavier (författare)
- Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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- Eshleman, Susan H (författare)
- Department of Pathology, Johns Hopkins University, MD, Baltimore, United States
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- Wagner, Ryan G. (författare)
- Umeå Centre for Global Health Research, Umeå, Sweden; Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; INDEPTH Network, Accra, Ghana
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- Mabuza, Wonderful (författare)
- Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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- Khoza, Nomhle (författare)
- Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa
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- Suchindran, Chirayath (författare)
- Carolina Population Center, University of North Carolina, NC, Chapel Hill, United States; Department of Biostatistics, University of North Carolina, NC, Chapel Hill, United States
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- Mokoena, Immitrude (författare)
- Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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- Twine, Rhian (författare)
- Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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- Andrew, Philip (författare)
- FHI 360, NC, Durham, United States
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- Townley, Ellen (författare)
- Division of AIDS–Henry M Jackson Foundation, Contractor to the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), MD, Baltimore, United States
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- Laeyendecker, Oliver (författare)
- Departments of Medicine and Epidemiology, Johns Hopkins University, MD, Baltimore, United States; Laboratory of Immunoregulation, NIAID, NIH, MD, Baltimore, United States
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- Agyei, Yaw (författare)
- Department of Pathology, Johns Hopkins University, MD, Baltimore, United States
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- Tollman, Stephen M. (författare)
- Umeå Centre for Global Health Research, Umeå, Sweden; Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; INDEPTH Network, Accra, Ghana
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- Kahn, Kathleen (författare)
- Umeå Centre for Global Health Research, Umeå, Sweden; Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; INDEPTH Network, Accra, Ghana
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(creator_code:org_t)
- Elsevier, 2016
- 2016
- Engelska.
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Ingår i: The Lancet Global Health. - : Elsevier. - 2214-109X. ; 4:12, s. e978-e988
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Cash transfers have been proposed as an intervention to reduce HIV-infection risk for young women in sub-Saharan Africa. However, scarce evidence is available about their effect on reducing HIV acquisition. We aimed to assess the effect of a conditional cash transfer on HIV incidence among young women in rural South Africa.Methods: We did a phase 3, randomised controlled trial (HPTN 068) in the rural Bushbuckridge subdistrict in Mpumalanga province, South Africa. We included girls aged 13–20 years if they were enrolled in school grades 8–11, not married or pregnant, able to read, they and their parent or guardian both had the necessary documentation necessary to open a bank account, and were residing in the study area and intending to remain until trial completion. Young women (and their parents or guardians) were randomly assigned (1:1), by use of numbered sealed envelopes containing a randomisation assignment card which were numerically ordered with block randomisation, to receive a monthly cash transfer conditional on school attendance (≥80% of school days per month) versus no cash transfer. Participants completed an Audio Computer-Assisted Self-Interview (ACASI), before test HIV counselling, HIV and herpes simplex virus (HSV)-2 testing, and post-test counselling at baseline, then at annual follow-up visits at 12, 24, and 36 months. Parents or guardians completed a Computer-Assisted Personal Interview at baseline and each follow-up visit. A stratified proportional hazards model was used in an intention-to-treat analysis of the primary outcome, HIV incidence, to compare the intervention and control groups. This study is registered at ClinicalTrials.gov (NCT01233531).Findings: Between March 5, 2011, and Dec 17, 2012, we recruited 10 134 young women and enrolled 2537 and their parents or guardians to receive a cash transfer programme (n=1225) or not (control group; n=1223). At baseline, the median age of girls was 15 years (IQR 14–17) and 672 (27%) had reported to have ever had sex. 107 incident HIV infections were recorded during the study: 59 cases in 3048 person-years in the intervention group and 48 cases in 2830 person-years in the control group. HIV incidence was not significantly different between those who received a cash transfer (1·94% per person-years) and those who did not (1·70% per person-years; hazard ratio 1·17, 95% CI 0·80–1·72, p=0·42).Interpretation: Cash transfers conditional on school attendance did not reduce HIV incidence in young women. School attendance significantly reduced risk of HIV acquisition, irrespective of study group. Keeping girls in school is important to reduce their HIV-infection risk.Funding: National Institute of Allergy and Infectious Diseases, National Institute of Mental Health of the National Institutes of Health.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Adolescent
- Counseling
- Female
- Herpesvirus 2
- Human
- HIV Infections
- Humans
- Incidence
- Motivation
- Risk Reduction Behavior
- South Africa
- Students
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- ref (ämneskategori)
- art (ämneskategori)
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Pettifor, Audrey
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MacPhail, Cather ...
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Hughes, James P
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Selin, Amanda
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Wang, Jing
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Gómez-Olivé, F X ...
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Eshleman, Susan ...
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Wagner, Ryan G.
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Mabuza, Wonderfu ...
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Khoza, Nomhle
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Suchindran, Chir ...
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Mokoena, Immitru ...
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Twine, Rhian
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Andrew, Philip
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Townley, Ellen
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Laeyendecker, Ol ...
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Agyei, Yaw
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Tollman, Stephen ...
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Kahn, Kathleen
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