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Change in brain amy...
Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment : a 3-year follow-up study
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- Rauhala, Elina (författare)
- Clinical Neurosciences, Faculty of Medicine, Turku University Hospital, University of Turku and Neurocenter, Turku, Finland
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- Johansson, Jarkko (författare)
- Umeå universitet,Diagnostisk radiologi,Turku PET Centre, Turku University Hospital, Turku, Finland
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- Karrasch, Mira (författare)
- Department of Psychology, Åbo Akademi University, Turku, Finland
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- Eskola, Olli (författare)
- Turku PET Centre, University of Turku, Turku, Finland
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- Tolvanen, Tuula (författare)
- Turku PET Centre, University of Turku, Turku, Finland; Department of Medical Physics, Turku University Hospital, Turku, Finland
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- Parkkola, Riitta (författare)
- Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland
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- Virtanen, Kirsi A. (författare)
- Turku PET Centre, Turku University Hospital, Turku, Finland
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- Rinne, Juha O. (författare)
- Turku PET Centre, Turku University Hospital, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland
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(creator_code:org_t)
- 2022-09-05
- 2022
- Engelska.
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Ingår i: EJNMMI Research. - : Springer. - 2191-219X. ; 12:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Our aim was to investigate the discriminative value of 18F-Flutemetamol PET in longitudinal assessment of amyloid beta accumulation in amnestic mild cognitive impairment (aMCI) patients, in relation to longitudinal cognitive changes.Methods: We investigated the change in 18F-Flutemetamol uptake and cognitive impairment in aMCI patients over time up to 3 years which enabled us to investigate possible association between changes in brain amyloid load and cognition over time. Thirty-four patients with aMCI (mean age 73.4 years, SD 6.6) were examined with 18F-Flutemetamol PET scan, brain MRI and cognitive tests at baseline and after 3-year follow-up or earlier if the patient had converted to Alzheimer´s disease (AD). 18F-Flutemetamol data were analyzed both with automated region-of-interest analysis and voxel-based statistical parametric mapping.Results: 18F-flutemetamol uptake increased during the follow-up, and the increase was significantly higher in patients who were amyloid positive at baseline as compared to the amyloid-negative ones. At follow-up, there was a significant association between 18F-Flutemetamol uptake and MMSE, logical memory I (immediate recall), logical memory II (delayed recall) and verbal fluency. An association was seen between the increase in 18F-Flutemetamol uptake and decline in MMSE and logical memory I scores.Conclusions: In the early phase of aMCI, presence of amyloid pathology at baseline strongly predicted amyloid accumulation during follow-up, which was further paralleled by cognitive declines. Inversely, some of our patients remained amyloid negative also at the end of the study without significant change in 18F-Flutemetamol uptake or cognition. Future studies with longer follow-up are needed to distinguish whether the underlying pathophysiology of aMCI in such patients is other than AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Alzheimer
- Amyloid PET
- Cognition
- Flutemetamol
- Follow-up
- Mild cognitive impairment
- Positron emission tomography
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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