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Design and methodol...
Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program
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- Robbins, Hilary A. (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Alcala, Karine (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Moez, Elham Khodayari (författare)
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada
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- Guida, Florence (författare)
- Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Thomas, Sera (författare)
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada
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- Zahed, Hana (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Warkentin, Matthew T. (författare)
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
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- Smith-Byrne, Karl (författare)
- Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
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- Brhane, Yonathan (författare)
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada
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- Muller, David (författare)
- Division of Genetic Medicine, Imperial College London School of Public Health, London, United Kingdom
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- Feng, Xiaoshuang (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Albanes, Demetrius (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
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- Aldrich, Melinda C. (författare)
- Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
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- Arslan, Alan A. (författare)
- Departments of Obstetrics and Gynecology and Population Health, New York University Grossman School of Medicine, NY, New York, United States
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- Bassett, Julie (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia
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- Berg, Christine D. (författare)
- Retired, MD, Bethesda
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- Cai, Qiuyin (författare)
- Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
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- Chen, Chu (författare)
- Program in Epidemiology and the Women's Health Initiative Clinical Coordinating Center, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Davies, Michael P.A. (författare)
- Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
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- Diergaarde, Brenda (författare)
- Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; UPMC Hillman Cancer Centre, PA, Pittsburgh, United States
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- Field, John K. (författare)
- Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
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- Freedman, Neal D. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
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- Huang, Wen-Yi (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
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- Johansson, Mikael (författare)
- Umeå universitet,Onkologi
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- Jones, Michael (författare)
- Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom
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- Koh, Woon-Puay (författare)
- Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore
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- Lam, Stephen (författare)
- Integrative Oncology, British Columbia Cancer Agency, Vancouver, Canada
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- Lan, Qing (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
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- Langhammer, Arnulf (författare)
- HUNT Research Center, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
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- Liao, Linda M. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
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- Liu, Geoffrey (författare)
- Computational Biology and Medicine Program, Princess Margaret Cancer Center, Toronto, Canada
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- Malekzadeh, Reza (författare)
- Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
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- Milne, Roger L. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Australia; School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
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- Montuenga, Luis M. (författare)
- Center of Applied Medical Research (CIMA) and Schools of Sciences and Medicine, University of Navarra, Pamplona, Spain; IDISNA, Pamplona, Spain; CIBERONC, Madrid, Spain
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- Rohan, Thomas (författare)
- Department of Epidemiology & Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
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- Sesso, Howard D. (författare)
- Brigham and Women's Hospital, Harvard Medical School, MA, Boston
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- Severi, Gianluca (författare)
- Inserm, Université Paris-Saclay, Villejuif, France
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- Sheikh, Mahdi (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Sinha, Rashmi (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
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- Shu, Xiao-Ou (författare)
- Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
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- Stevens, Victoria L. (författare)
- Rollins School of Public Health, Emory University, GA, Atlanta
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- Tammemägi, Martin C. (författare)
- Department of Health Sciences, Brock University, ON, St. Cathaarines, Canada; Prevention and Cancer Control, Ontario Health, ON, Toronto, Canada
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- Tinker, Lesley F. (författare)
- Women's Health Initiative Clinical Coordinating Center, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Visvanathan, Kala (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore
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- Wang, Ying (författare)
- American Cancer Society, GA, Atlanta
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- Wang, Renwei (författare)
- UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States
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- Weinstein, Stephanie J. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
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- White, Emily (författare)
- Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Wilson, David (författare)
- Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, PA, Pittsburgh, United States
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- Yuan, Jian-Min (författare)
- UPMC Hillman Cancer Centre, PA, Pittsburgh, United States; Department of Epidemiology, Graduate Schoolf of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
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- Zhang, Xuehong (författare)
- Brigham and Women's Hospital, Harvard Medical School, MA, Boston
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- Zheng, Wei (författare)
- Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
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- Amos, Christopher I. (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
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- Brennan, Paul (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Johansson, Mattias (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Hung, Rayjean J. (författare)
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Annals of Epidemiology. - : Elsevier. - 1047-2797 .- 1873-2585. ; 77, s. 1-12
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) program is an NCI-funded initiative with an objective to develop tools to optimize low-dose CT (LDCT) lung cancer screening. Here, we describe the rationale and design for the Risk Biomarker and Nodule Malignancy projects within INTEGRAL. The overarching goal of these projects is to systematically investigate circulating protein markers to include on a panel for use (i) pre-LDCT, to identify people likely to benefit from screening, and (ii) post-LDCT, to differentiate benign versus malignant nodules. To identify informative proteins, the Risk Biomarker project measured 1161 proteins in a nested-case control study within 2 prospective cohorts (n = 252 lung cancer cases and 252 controls) and replicated associations for a subset of proteins in 4 cohorts (n = 479 cases and 479 controls). Eligible participants had a current or former history of smoking and cases were diagnosed up to 3 years following blood draw. The Nodule Malignancy project measured 1078 proteins among participants with a heavy smoking history within four LDCT screening studies (n = 425 cases diagnosed up to 5 years following blood draw, 430 benign-nodule controls, and 398 nodule-free controls). The INTEGRAL panel will enable absolute quantification of 21 proteins. We will evaluate its performance in the Risk Biomarker project using a case-cohort study including 14 cohorts (n = 1696 cases and 2926 subcohort representatives), and in the Nodule Malignancy project within five LDCT screening studies (n = 675 cases, 680 benign-nodule controls, and 648 nodule-free controls). Future progress to advance lung cancer early detection biomarkers will require carefully designed validation, translational, and comparative studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- biomarker discovery and validation
- biomarkers
- early detection
- Lung cancer screening
- nodule malignancy
- risk prediction
- study design
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Robbins, Hilary ...
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Alcala, Karine
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Moez, Elham Khod ...
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Guida, Florence
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Thomas, Sera
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Zahed, Hana
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Warkentin, Matth ...
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Smith-Byrne, Kar ...
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Brhane, Yonathan
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Muller, David
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Feng, Xiaoshuang
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Albanes, Demetri ...
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Aldrich, Melinda ...
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Arslan, Alan A.
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Bassett, Julie
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Berg, Christine ...
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Cai, Qiuyin
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Chen, Chu
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Davies, Michael ...
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Diergaarde, Bren ...
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Field, John K.
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Freedman, Neal D ...
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Huang, Wen-Yi
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Johansson, Mikae ...
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Jones, Michael
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Koh, Woon-Puay
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Lam, Stephen
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Lan, Qing
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Langhammer, Arnu ...
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Liao, Linda M.
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Liu, Geoffrey
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Malekzadeh, Reza
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Milne, Roger L.
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Montuenga, Luis ...
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Rohan, Thomas
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Sesso, Howard D.
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Severi, Gianluca
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Sheikh, Mahdi
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Sinha, Rashmi
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Shu, Xiao-Ou
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Stevens, Victori ...
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Tammemägi, Marti ...
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Tinker, Lesley F ...
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Visvanathan, Kal ...
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Wang, Ying
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Wang, Renwei
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Weinstein, Steph ...
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White, Emily
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Wilson, David
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Yuan, Jian-Min
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Zhang, Xuehong
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Zheng, Wei
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Amos, Christophe ...
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Brennan, Paul
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Johansson, Matti ...
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Hung, Rayjean J.
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