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Circulating amino a...
Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts
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- Rothwell, Joseph A. (författare)
- Centre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, France
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- Bešević, Jelena (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Dimou, Niki (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Breeur, Marie (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Murphy, Neil (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Wedekind, Roland (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Viallon, Vivian (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Ferrari, Pietro (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Achaintre, David (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Gicquiau, Audrey (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Rinaldi, Sabina (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Scalbert, Augustin (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Huybrechts, Inge (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Prehn, Cornelia (författare)
- Metabolomics and Proteomics Core, Helmholtz Zentrum München, Neuherberg, Germany
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- Adamski, Jerzy (författare)
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, Singapore; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana, Slovenia
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- Cross, Amanda J. (författare)
- School of Public Health, Imperial College London, London, United Kingdom
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- Keun, Hector (författare)
- Department of Surgery & Cancer, Imperial College London, London, United Kingdom
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- Chadeau-Hyam, Marc (författare)
- School of Public Health, Imperial College London, London, United Kingdom
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- Boutron-Ruault, Marie-Christine (författare)
- Centre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, France
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- Overvad, Kim (författare)
- Department of Public Health, Aarhus University, Bartholins Allé 2, Aarhus, Denmark
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- Dahm, Christina C. (författare)
- Department of Public Health, Aarhus University, Bartholins Allé 2, Aarhus, Denmark
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- Nøst, Therese Haugdahl (författare)
- Faculty of Health Sciences, Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway
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- Sandanger, Torkjel M. (författare)
- Faculty of Health Sciences, Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway
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- Skeie, Guri (författare)
- Faculty of Health Sciences, Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway
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- Zamora-Ros, Raul (författare)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
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- Tsilidis, Kostas K. (författare)
- School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
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- Eichelmann, Fabian (författare)
- German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
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- Schulze, Matthias B. (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Vidman, Linda (författare)
- Umeå universitet,Onkologi
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- Sánchez, Maria-José (författare)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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- Amiano, Pilar (författare)
- Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
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- Ardanaz, Eva (författare)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Leyre 15, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
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- Smith-Byrne, Karl (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France
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- Travis, Ruth (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Katzke, Verena (författare)
- German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
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- Kaaks, Rudolf (författare)
- German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
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- Derksen, Jeroen W. G. (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Colorado-Yohar, Sandra (författare)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
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- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Department, Provincial Health Authority (ASP), Ragusa, Italy
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- Bueno-de-Mesquita, Bas (författare)
- Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1, BA, Bilthoven, Netherlands
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- Vineis, Paolo (författare)
- School of Public Health, Imperial College London, London, United Kingdom; Italian Institute of Technology, Genova, Italy
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- Palli, Domenico (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy
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- Pasanisi, Fabrizio (författare)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Eriksen, Anne Kirstine (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49, Copenhagen, Denmark
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- Severi, Gianluca (författare)
- Centre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science, Applications “G. Parenti” University of Florence, Florence, Italy
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France; School of Public Health, Imperial College London, London, United Kingdom
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(creator_code:org_t)
- 2023-02-28
- 2023
- Engelska.
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Ingår i: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 21:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts.Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases.Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded.Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Amino acids
- Colorectal cancer
- Glutamine
- Histidine
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Rothwell, Joseph ...
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Bešević, Jelena
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Dimou, Niki
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Breeur, Marie
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Murphy, Neil
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Jenab, Mazda
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visa fler...
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Wedekind, Roland
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Viallon, Vivian
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Ferrari, Pietro
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Achaintre, David
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Gicquiau, Audrey
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Rinaldi, Sabina
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Scalbert, August ...
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Huybrechts, Inge
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Prehn, Cornelia
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Adamski, Jerzy
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Cross, Amanda J.
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Keun, Hector
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Chadeau-Hyam, Ma ...
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Boutron-Ruault, ...
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Overvad, Kim
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Dahm, Christina ...
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Nøst, Therese Ha ...
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Sandanger, Torkj ...
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Skeie, Guri
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Zamora-Ros, Raul
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Tsilidis, Kostas ...
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Eichelmann, Fabi ...
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Schulze, Matthia ...
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van Guelpen, Bet ...
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Vidman, Linda
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Sánchez, Maria-J ...
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Amiano, Pilar
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Ardanaz, Eva
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Smith-Byrne, Kar ...
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Travis, Ruth
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Katzke, Verena
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Kaaks, Rudolf
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Derksen, Jeroen ...
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Colorado-Yohar, ...
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Tumino, Rosario
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Bueno-de-Mesquit ...
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Vineis, Paolo
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Palli, Domenico
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Pasanisi, Fabriz ...
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Eriksen, Anne Ki ...
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Tjønneland, Anne
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Severi, Gianluca
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Gunter, Marc J.
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