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Sökning: id:"swepub:oai:DiVA.org:umu-206343" > Prediagnostic serum...

Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients

Mao, Ziling (författare)
Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
Baker, Jacqueline Roshelli (författare)
Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States
Takeuchi, Masayoshi (författare)
Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan
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Hyogo, Hideyuki (författare)
Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan; Lifecare Clinic Hiroshima, Hiroshima, Japan
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Diet, Cancer and Health, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Eriksen, Anne Kirstine (författare)
Danish Cancer Society Research Center, Diet, Cancer and Health, Copenhagen, Denmark
Severi, Gianluca (författare)
UVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France; Department of Statistics, Computer Science Applications, “G. Parenti” University of Florence, Florence, Italy
Rothwell, Joseph (författare)
UVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France
Laouali, Nasser (författare)
UVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France
Katzke, Verena (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Schulze, Matthias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
Palli, Domenico (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy
Sieri, Sabina (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy
de Magistris, Maria Santucci (författare)
Azienda Ospedaliera Universitaria Federico II, Naples, Italy
Tumino, Rosario (författare)
Hyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy
Sacerdote, Carlotta (författare)
Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy
Derksen, Jeroen W. G. (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
Gram, Inger T. (författare)
Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway
Skeie, Guri (författare)
Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway
Sandanger, Torkjel M. (författare)
Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway
Quirós, Jose Ramón (författare)
Public Health Directorate, Asturias, Spain
Crous-Bou, Marta (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Sánchez, Maria-Jose (författare)
Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
Amiano, Pilar (författare)
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute, San Sebastián, Spain
Colorado-Yohar, Sandra M. (författare)
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
Guevara, Marcela (författare)
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
Harlid, Sophia, 1978- (författare)
Umeå universitet,Institutionen för strålningsvetenskaper
Johansson, Ingegerd (författare)
Umeå universitet,Institutionen för odontologi
Perez-Cornago, Aurora (författare)
Cancer Epidemiology Unit (CEU), Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom
Freisling, Heinz (författare)
Section of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France
Gunter, Marc (författare)
Section of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France
Weiderpass, Elisabete (författare)
Office of the Director, International Agency for Research on Cancer (IARC-WHO), Lyon, France
Heath, Alicia K. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Aglago, Elom (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Jenab, Mazda (författare)
Section of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France
Fedirko, Veronika (författare)
Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; MD Anderson Cancer Center, TX, Houston, United States
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 (creator_code:org_t)
2023-03-20
2023
Engelska.
Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 152:11, s. 2257-2268
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04-2.25, Ptrend =.002) and all-cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16-2.26, Ptrend <.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74-1.42; HRdistal colon = 1.51, 95% CI: 1.20-1.91; Peffect modification =.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)

Nyckelord

advanced glycation end products
colorectal cancer
glyceraldehyde-derived advanced glycation end products
mortality
prospective study

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