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Latent heterogeneit...
Latent heterogeneity of muscle-invasive bladder cancer in patient characteristics and survival : a population-based nation-wide study in the Bladder Cancer Data Base Sweden (BladderBaSe)
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- Häggström, Christel (författare)
- Uppsala universitet,Uppsala University,Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Translational Oncology & Urology Research (TOUR), School of Cancer and Pharmaceutical Sciences, King's College, London, United Kingdom,Endokrinkirurgi,Umeå Univ, Dept Publ Hlth & Clin Med, Northern Registry Ctr, Umeå, Sweden; Kings Coll London, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol Res TOUR, London, England
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- Rowley, Mark (författare)
- Saddle Point Science, York, United Kingdom; Saddle Point Science Europe, Nijmegen, Netherlands,Saddle Point Sci, York, England.;Saddle Point Sci Europe, Nijmegen, Netherlands.
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- Liedberg, Fredrik (författare)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Dept Urol, Malmö, Sweden.;Lund Univ, Inst Translat Med, Malmö, Sweden.
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- Coolen, Anthony C. C. (författare)
- Saddle Point Science, York, United Kingdom; Saddle Point Science Europe, Nijmegen, Netherlands; Department of Biophysics, Faculty of Science, Donders Institute, Radboud University, Nijmegen, Netherlands,Saddle Point Sci, York, England.;Saddle Point Sci Europe, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst, Fac Sci, Dept Biophys, Nijmegen, Netherlands.
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- Holmberg, Lars (författare)
- Uppsala universitet,Uppsala University,King's College London,Endokrinkirurgi,Kings Coll London, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol Res TOUR, London, England
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(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- Engelska.
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Ingår i: Cancer Medicine. - : John Wiley & Sons. - 2045-7634. ; 12:12, s. 13856-13864
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Patients with muscle-invasive bladder cancer (MIBC) constitute a heterogenous group in terms of patient and tumour characteristics (‘case-mix’) and prognosis. The aim of the current study was to investigate whether differences in survival could be used to separate MIBC patients into separate classes using a recently developed latent class regression method for survival analysis with competing risks.Methods: We selected all participants diagnosed with MIBC in the Bladder Cancer Data Base Sweden (BladderBase) and analysed inter-patient heterogeneity in risk of death from bladder cancer and other causes.Results: Using data from 9653 MIBC patients, we detected heterogeneity with six distinct latent classes in the studied population. The largest, and most frail class included 50% of the study population and was characterised by a somewhat larger proportion of women, higher age at diagnosis, more advanced disease and lower probability of curative treatment. Despite this, patients in this class treated with curative intent by radical cystectomy or radiotherapy had a lower association to risk of death. The second largest class included 23% and was substantially less frail as compared to the largest class. The third and fourth class included each around 9%–10%, whereas the fifth and sixth class included each 3%–4% of the population.Conclusions: Results from the current study are compatible with previous research and the method can be used to adjust comparisons in prognosis between MIBC populations for influential differences in the distribution of sub-classes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- bladder cancer
- competing risks
- latent class
- survival analysis
- bladder cancer
- competing risks
- latent class
- survival analysis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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