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Sökning: id:"swepub:oai:DiVA.org:umu-211797" > Metabolically (un)h...

Metabolically (un)healthy obesity and risk of obesity-related cancers : a pooled study

Sun, Ming (författare)
Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LUCC: Lund University Cancer Centre,Other Strong Research Environments
Fritz, Josef (författare)
Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Medical University of Innsbruck
Häggström, Christel (författare)
Uppsala University,Umeå University,Uppsala universitet,Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden,Endokrinkirurgi,Umeå Univ, Northern Register Ctr, Dept Publ Hlth & Clin Med, Umeå, Sweden
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Bjørge, Tone (författare)
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Section for Cervical Cancer Screening, Cancer Registry of Norway, Oslo, Norway,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Canc Registry Norway, Sect Cerv Canc Screening, Oslo, Norway.,Cancer Registry of Norway, Institute of Population-Based Cancer Research
Nagel, Gabriele (författare)
Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany; Agency for Preventive and Social Medicine, (aks), Bregenz, Austria,Ulm Univ, Inst Epidemiol & Med Biometry, Ulm, Germany.;Agcy Prevent & Social Med, Bregenz, Aks, Austria.,Agency for Preventive and Social Medicine Vorarlberg
Manjer, Jonas (författare)
Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
Engeland, Anders (författare)
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Chronic Diseases, Norwegian Institute of Public Health, Bergen, Norway,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Norwegian Inst Publ Hlth, Dept Chron Dis, Bergen, Norway.
Zitt, Emanuel (författare)
Agency for Preventive and Social Medicine, (aks), Bregenz, Austria; Department of Internal Medicine III (Nephrology and Dialysis), Academic Teaching Hospital Feldkirch, Feldkirch, Austria; Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria,Agcy Prevent & Social Med, Bregenz, Aks, Austria.;Acad Teaching Hosp Feldkirch, Dept Internal Med Nephrol & Dialysis 3, Feldkirch, Austria.;Acad Teaching Hosp Feldkirch, Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria.,Landeskrankenhaus Feldkirch
van Guelpen, Bethany (författare)
Umeå University,Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi,Umeå Univ, Dept Radiat Sci, Oncol, Umeå, Sweden.;Umeå Univ, Wallenberg Ctr Mol Med, Umeå, Sweden.
Stattin, Pär (författare)
Uppsala University,Uppsala universitet,Urologkirurgi
Ulmer, Hanno (författare)
Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria,Med Univ Innsbruck, Inst Med Stat & Informat, Innsbruck, Austria.
Stocks, Tanja (författare)
Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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 (creator_code:org_t)
2023-01-17
2023
Engelska.
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 115:4, s. 456-467
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://uu.diva-port... (primary) (Raw object)
http://dx.doi.org/10... (free)
https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
https://lup.lub.lu.s...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Studies of obesity with or without metabolic aberrations, commonly termed metabolically unhealthy or healthy obesity, in relation to cancer risk are scarce.Methods: We investigated body mass index (normal weight, overweight, obesity) jointly and in interaction with metabolic health status in relation to obesity-related cancer risk (n = 23630) among 797193 European individuals. A metabolic score comprising mid-blood pressure, plasma glucose, and triglycerides was used to define metabolically healthy and unhealthy status. Hazard ratios (HRs) and multiplicative interactions were assessed using Cox regression, and additive interactions were assessed using the relative excess risk for interaction. All statistical tests were 2-sided.Results: Metabolically unhealthy obesity, with a baseline prevalence of 7%, was, compared with metabolically healthy normal weight, associated with an increased relative risk of any obesity-related cancer and of colon, rectal, pancreas, endometrial, liver, gallbladder, and renal cell cancer (P <. 05), with the highest risk estimates for endometrial, liver, and renal cell cancer (HR = 2.55-3.00). Metabolically healthy obesity showed a higher relative risk for any obesity-related cancer and colon (in men), endometrial, renal cell, liver, and gallbladder cancer, though the risk relationships were weaker. There were no multiplicative interactions, but there were additive, positive interactions between body mass index and metabolic health status on obesity-related and rectal cancer among men and on endometrial cancer (P <. 05).Conclusions: This study highlights that the type of metabolic obesity phenotype is important when assessing obesity-related cancer risk. In general, metabolic aberrations further increased the obesity-induced cancer risk, suggesting that obesity and metabolic aberrations are useful targets for prevention.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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