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Isoallopregnanolone...
Isoallopregnanolone inhibits estrus cycle-dependent aggressive behavior
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- Bäckström, Torbjörn (författare)
- Umeå universitet,Obstetrik och gynekologi
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- Bengtsson, Sara K. S. (författare)
- Umeå universitet,Obstetrik och gynekologi
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- Sjöstedt, Jessica (författare)
- Umeå universitet,Obstetrik och gynekologi
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- Malinina, Evgenya (författare)
- Umeå universitet,Obstetrik och gynekologi
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- Johansson, Inga-Maj (författare)
- Umeå universitet,Obstetrik och gynekologi
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- Ragagnin, Gianna (författare)
- Umeå universitet,Obstetrik och gynekologi
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- Ekberg, Karin (författare)
- Asarina Pharma AB, Solna, Sweden
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- Lundgren, Per, 1966- (författare)
- Umeå universitet,Obstetrik och gynekologi
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(creator_code:org_t)
- MDPI, 2023
- 2023
- Engelska.
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Ingår i: Biomolecules. - : MDPI. - 2218-273X. ; 13:6
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Among female rats, some individuals show estrus cycle-dependent irritability/aggressive behaviors, and these individual rats may be used as a model for premenstrual dysphoric disorder (PMDD). We wanted to investigate if these behaviors are related to the estrus cycle phase containing moderately increased levels of positive GABA-A receptor-modulating steroids (steroid-PAM), especially allopregnanolone (ALLO), and if the adverse behavior can be antagonized. The electrophysiology studies in this paper show that isoallopregnanolone (ISO) is a GABA-A-modulating steroid antagonist (GAMSA), meaning that ISO can antagonize the agonistic effects of positive GABA-A receptor-modulating steroids in both α1β2γ2L and α4β3δ GABA-A receptor subtypes. In this study, we also investigated whether ISO could antagonize the estrus cycle-dependent aggressive behaviors in female Wistar rats using a resident–intruder test. Our results confirmed previous reports of estrus cycle-dependent behaviors in that 42% of the tested rats showed higher levels of irritability/aggression at diestrus compared to those at estrus. Furthermore, we found that, during the treatment with ISO, the aggressive behavior at diestrus was alleviated to a level comparable to that of estrus. We noticed an 89% reduction in the increase in aggressive behavior at diestrus compared to that at estrus. Vehicle treatment in the same animals showed a minimal effect on the diestrus-related aggressive behavior. In conclusion, we showed that ISO can antagonize Steroid-PAM both in α1β2γ2L and α4β3δ GABA-A receptor subtypes and inhibit estrus cycle-dependent aggressive behavior.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- allopregnanolone
- diestrus
- estrus
- estrus cycle
- estrus cycle-dependent aggression
- isoallopregnanolone
- resident/intruder test
- Wistar rats
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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