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Lung cancer risk di...
Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools
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- Feng, Xiaoshuang (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Wu, Wendy Yi-Ying (författare)
- Umeå universitet,Onkologi
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- Onwuka, Justina Ucheojor (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Haider, Zahra (författare)
- Umeå universitet,Onkologi
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- Alcala, Karine (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Smith-Byrne, Karl (författare)
- Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
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- Zahed, Hana (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Guida, Florence (författare)
- Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Wang, Renwei (författare)
- Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States
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- Bassett, Julie K. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia
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- Stevens, Victoria (författare)
- Rollins School of Public Health, Emory University, GA, Atlanta, United States
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- Wang, Ying (författare)
- American Cancer Society, GA, Atlanta, United States
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- Weinstein, Stephanie (författare)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States
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- Freedman, Neal D. (författare)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States
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- Chen, Chu (författare)
- Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Tinker, Lesley (författare)
- Women's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Nøst, Therese Haugdahl (författare)
- Department of Community Medicine, University of Tromsø, Arctic University of Norway, Tromsø, Norway
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- Koh, Woon-Puay (författare)
- Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore
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- Muller, David (författare)
- Division of Genetic Medicine, Imperial College London School of Public Health, London, United Kingdom
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- Colorado-Yohar, Sandra M. (författare)
- Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
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- Tumino, Rosario (författare)
- Hyblean Association for Epidemiological Research, Ragusa, Italy
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- Hung, Rayjean J. (författare)
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
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- Amos, Christopher I. (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
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- Lin, Xihong (författare)
- Department of Biostatistics, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Statistics, Harvard University, MA, Cambridge, United States
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- Zhang, Xuehong (författare)
- Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States
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- Arslan, Alan A. (författare)
- Department of Population Health, New York University School of Medicine, New York, NY, USA
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- Sánchez, Maria-Jose (författare)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ib, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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- Sørgjerd, Elin Pettersen (författare)
- HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway
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- Severi, Gianluca (författare)
- Inserm, Université Paris-Saclay, Villejuif, France
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- Hveem, Kristian (författare)
- HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway
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- Brennan, Paul (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Langhammer, Arnulf (författare)
- HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
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- Milne, Roger L. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia
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- Yuan, Jian-Min (författare)
- Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
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- Melin, Beatrice S. (författare)
- Umeå universitet,Onkologi
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- Johansson, Mikael (författare)
- Umeå universitet,Onkologi
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- Robbins, Hilary A. (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Johansson, Mattias (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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(creator_code:org_t)
- Oxford University Press, 2023
- 2023
- Engelska.
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 115:9, s. 1050-1059
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with a smoking-based risk model (PLCOm2012) and a commercially available autoantibody biomarker test.METHODS: We designed a case-control study nested in 6 prospective cohorts, including 624 lung cancer participants who donated blood samples at most 3 years prior to lung cancer diagnosis and 624 smoking-matched cancer free participants who were assayed for 302 proteins. We used 470 case-control pairs from 4 cohorts to select proteins and train a protein-based risk model. We subsequently used 154 case-control pairs from 2 cohorts to compare the risk-discriminatory performance of the protein-based model with that of the Early Cancer Detection Test (EarlyCDT)-Lung and the PLCOm2012 model using receiver operating characteristics analysis and by estimating models' sensitivity. All tests were 2-sided.RESULTS: The area under the curve for the protein-based risk model in the validation sample was 0.75 (95% confidence interval [CI] = 0.70 to 0.81) compared with 0.64 (95% CI = 0.57 to 0.70) for the PLCOm2012 model (Pdifference = .001). The EarlyCDT-Lung had a sensitivity of 14% (95% CI = 8.2% to 19%) and a specificity of 86% (95% CI = 81% to 92%) for incident lung cancer. At the same specificity of 86%, the sensitivity for the protein-based risk model was estimated at 49% (95% CI = 41% to 57%) and 30% (95% CI = 23% to 37%) for the PLCOm2012 model.CONCLUSION: Circulating proteins showed promise in predicting incident lung cancer and outperformed a standard risk prediction model and the commercialized EarlyCDT-Lung.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Feng, Xiaoshuang
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Wu, Wendy Yi-Yin ...
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Onwuka, Justina ...
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Haider, Zahra
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Alcala, Karine
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Smith-Byrne, Kar ...
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visa fler...
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Zahed, Hana
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Guida, Florence
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Wang, Renwei
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Bassett, Julie K ...
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Stevens, Victori ...
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Wang, Ying
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Weinstein, Steph ...
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Freedman, Neal D ...
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Chen, Chu
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Tinker, Lesley
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Nøst, Therese Ha ...
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Koh, Woon-Puay
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Muller, David
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Colorado-Yohar, ...
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Tumino, Rosario
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Hung, Rayjean J.
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Amos, Christophe ...
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Lin, Xihong
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Zhang, Xuehong
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Arslan, Alan A.
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Sánchez, Maria-J ...
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Sørgjerd, Elin P ...
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Severi, Gianluca
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Hveem, Kristian
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Brennan, Paul
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Langhammer, Arnu ...
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Milne, Roger L.
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Yuan, Jian-Min
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Melin, Beatrice ...
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Johansson, Mikae ...
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Robbins, Hilary ...
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Johansson, Matti ...
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