SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:umu-216198"
 

Sökning: id:"swepub:oai:DiVA.org:umu-216198" > Stoma-free survival...

Stoma-free survival after rectal cancer resection with anastomotic leakage : development and validation of a prediction model in a large international cohort

Greijdanus, Nynke G. (författare)
Department of Surgery, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands
Wienholts, Kiedo (författare)
Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Netherlands; Treatment and Quality of Life, Cancer Center Amsterdam, Amsterdam, Netherlands; Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands
Ubels, Sander (författare)
Department of Surgery, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands
visa fler...
Talboom, Kevin (författare)
Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Netherlands; Treatment and Quality of Life, Cancer Center Amsterdam, Amsterdam, Netherlands; Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands
Hannink, Gerjon (författare)
Department of Medical Imaging, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands
Wolthuis, Albert (författare)
Department of Surgery, Uz Leuven, Leuven, Belgium
De Lacy, Francisco B. (författare)
Department of Gastrointestinal Surgery, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain
Lefevre, Jérémie H. (författare)
Department of Digestive Surgery, Sorbonne Université, AP-HP, Hôpital Saint Antoine, Paris, France
Solomon, Michael (författare)
Department of Surgery, University of Sydney Central Clinical School, NSW, Camperdown, Australia
Frasson, Matteo (författare)
Department of Surgery, Valencia University Hospital la Fe, Valencia, Spain
Rotholtz, Nicolas (författare)
§§ Department of Surgery, Hospital Alemán, Buenos Aires, Argentina
Denost, Quentin (författare)
Bordeaux Colorectal Institute, Clinique Tivoli, Bordeaux, France
Perez, Rodrigo O. (författare)
Department of Colorectal Surgery, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil
Konishi, Tsuyoshi (författare)
Department of Colon and Rectal Surgery, Division of Surgery, The University of Texas Md Anderson Cancer Center, TX, Houston, United States
Panis, Yves (författare)
Department of Colorectal Surgery, Colorectal Surgery Center, Groupe Hospitalier Privé Ambroise Paré-Hartmann, Neuilly Seine, France
Rutegård, Martin, 1982- (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för kirurgisk och perioperativ vetenskap
Hompes, Roel (författare)
Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Netherlands; Treatment and Quality of Life, Cancer Center Amsterdam, Amsterdam, Netherlands; Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands
Rosman, Camiel (författare)
Department of Surgery, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands
Van Workum, Frans (författare)
Department of Surgery, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
Tanis, Pieter J. (författare)
Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Netherlands; Treatment and Quality of Life, Cancer Center Amsterdam, Amsterdam, Netherlands; Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands; Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus Medical Centre, Rotterdam, Netherlands
De Wilt, Johannes H.W. (författare)
Department of Surgery, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands
visa färre...
 (creator_code:org_t)
Wolters Kluwer, 2023
2023
Engelska.
Ingår i: Annals of Surgery. - : Wolters Kluwer. - 0003-4932 .- 1528-1140. ; 278:5, s. 772-780
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Objective: To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL).Background: AL after RC resection often results in a permanent stoma.Methods: This international retrospective cohort study (TENTACLE-Rectum) encompassed 216 participating centres and included patients who developed AL after RC surgery between 2014 and 2018. Clinically relevant predictors for 1-year stoma-free survival were included in uni and multivariable logistic regression models. The STOMA score was developed and internally validated in a cohort of patients operated between 2014 and 2017, with subsequent temporal validation in a 2018 cohort. The discriminative power and calibration of the models' performance were evaluated.Results: This study included 2499 patients with AL, 1954 in the development cohort and 545 in the validation cohort. Baseline characteristics were comparable. One-year stoma-free survival was 45.0% in the development cohort and 43.7% in the validation cohort. The following predictors were included in the STOMA score: sex, age, American Society of Anestesiologist classification, body mass index, clinical M-disease, neoadjuvant therapy, abdominal and transanal approach, primary defunctioning stoma, multivisceral resection, clinical setting in which AL was diagnosed, postoperative day of AL diagnosis, abdominal contamination, anastomotic defect circumference, bowel wall ischemia, anastomotic fistula, retraction, and reactivation leakage. The STOMA score showed good discrimination and calibration (c-index: 0.71, 95% CI: 0.66-0.76).Conclusions: The STOMA score consists of 18 clinically relevant factors and estimates the individual risk for 1-year stoma-free survival in patients with AL after RC surgery, which may improve patient counseling and give guidance when analyzing the efficacy of different treatment strategies in future studies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Nyckelord

anastomotic leakage
logistic regression model
permanent stoma
prediction model
rectal cancer
rectal cancer resection
STOMA score
stoma-free survival

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy