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Sökning: id:"swepub:oai:DiVA.org:umu-218306" > Body mass index, tr...

Body mass index, triglyceride-glucose index, and prostate cancer death : a mediation analysis in eight European cohorts

Fritz, Josef (författare)
Lund University,Lunds universitet,Department of Translational Medicine, Lund University, Malmö, Sweden; Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Registerbaserad epidemiologi - Stocks,Institutionen för translationell medicin,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Register-based epidemiology,Faculty of Medicine
Jochems, Sylvia H.J. (författare)
Lund University,Lunds universitet,Department of Clinical Sciences Lund, Lund University, Lund, Sweden,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Registerbaserad epidemiologi - Stocks,Institutionen för translationell medicin,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Register-based epidemiology,Department of Translational Medicine,Faculty of Medicine
Bjørge, Tone (författare)
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Cancer Registry of Norway, Oslo, Norway,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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Wood, Angela M. (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Häggström, Christel (författare)
Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Northern Registry Centre
Ulmer, Hanno (författare)
Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria; Agency for Preventive and Social Medicine (aks), Bregenz, Austria
Nagel, Gabriele (författare)
Agency for Preventive and Social Medicine (aks), Bregenz, Austria; Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
Zitt, Emanuel (författare)
Agency for Preventive and Social Medicine (aks), Bregenz, Austria; Department of Internal Medicine 3, LKH Feldkirch, Feldkirch, Austria; Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria,Landeskrankenhaus Feldkirch
Engeland, Anders (författare)
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Chronic Diseases, Norwegian Institute of Public Health, Bergen, Norway
Harlid, Sophia, 1978- (författare)
Umeå University,Umeå universitet,Onkologi
Drake, Isabel (författare)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Diabetes - Cardiovascular Disease,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
Stattin, Pär (författare)
Uppsala University
Stocks, Tanja (författare)
Lund University,Lunds universitet,Department of Translational Medicine, Lund University, Malmö, Sweden; Department of Clinical Sciences Lund, Lund University, Lund, Sweden,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Registerbaserad epidemiologi - Stocks,Institutionen för translationell medicin,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Register-based epidemiology,Faculty of Medicine
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 (creator_code:org_t)
Nature Publishing Group, 2024
2024
Engelska.
Ingår i: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 130, s. 308-316
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
http://dx.doi.org/10... (free)
https://urn.kb.se/re...
https://doi.org/10.1...
https://lup.lub.lu.s...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Insulin resistance is a hypothesised biological mechanism linking obesity with prostate cancer (PCa) death. Data in support of this hypothesis is limited.Methods: We included 259,884 men from eight European cohorts, with 11,760 incident PCa’s and 1784 PCa deaths during follow-up. We used the triglyceride-glucose (TyG) index as indicator of insulin resistance. We analysed PCa cases with follow-up from PCa diagnosis, and the full cohort with follow-up from the baseline cancer-free state, thus incorporating both PCa incidence and death. We calculated hazard ratios (HR) and the proportion of the total effect of body mass index (BMI) on PCa death mediated through TyG index.Results: In the PCa-case-only analysis, baseline TyG index was positively associated with PCa death (HR per 1-standard deviation: 1.11, 95% confidence interval (CI); 1.01–1.22), and mediated a substantial proportion of the baseline BMI effect on PCa death (HRtotal effect per 5-kg/m2 BMI: 1.24; 1.14–1.35, of which 28%; 4%–52%, mediated). In contrast, in the full cohort, the TyG index was not associated with PCa death (HR: 1.03; 0.94-1.13), hence did not substantially mediate the effect of BMI on PCa death.Conclusions: Insulin resistance could be an important pathway through which obesity accelerates PCa progression to death.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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