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Allometric versus t...
Allometric versus traditional body-shape indices and risk of colorectal cancer : a Mendelian randomization analysis
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- Rontogianni, Marina O. (författare)
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
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- Bouras, Emmanouil (författare)
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Hygiene, Social-Preventive Medicine and Medical Statistics, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece
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- Aglago, Elom Kouassivi (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, United Kingdom
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- Freisling, Heinz (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Murphy, Neil (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Cotterchio, Michelle (författare)
- Ontario Health (Cancer Care Ontario), ON, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, ON, Toronto, Canada
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- Hampe, Jochen (författare)
- Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany
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- Lindblom, Annika (författare)
- Karolinska Institutet
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- Pai, Rish K. (författare)
- Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States
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- Pharoah, Paul D. P. (författare)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Phipps, Amanda I. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- van Duijnhoven, Franzel J. B. (författare)
- Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
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- Visvanathan, Kala (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Li, Christopher I. (författare)
- Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States; Translational Research Program and Epidemiology Program, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Pellatt, Andrew J. (författare)
- Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, TX, Texas, United States
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- Ogino, Shuji (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States; Program in Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, MA, Boston, United States
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- Gunter, Marc J. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, United Kingdom
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- Peters, Ulrike (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- Christakoudi, Sofia (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, United Kingdom; Department of Inflammation Biology, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
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- Tsilidis, Konstantinos K. (författare)
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, United Kingdom
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(creator_code:org_t)
- Springer Nature, 2024
- 2024
- Engelska.
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Ingår i: International Journal of Obesity. - : Springer Nature. - 0307-0565 .- 1476-5497. ; 48, s. 709-716
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but are correlated with Body Mass Index (BMI), and adjustment for BMI introduces a strong correlation with height. Thus, new allometric indices have been developed, namely A Body Shape Index (ABSI), Hip Index (HI), and Waist-to-Hip Index (WHI), which are uncorrelated with weight and height; these have also been associated with CRC risk in observational studies, but information from Mendelian randomization (MR) studies is missing.Methods: We used two-sample MR to examine potential causal cancer site- and sex-specific associations of the genetically-predicted allometric body-shape indices with CRC risk, and compared them with BMI-adjusted traditional body-shape indices, and BMI. Data were obtained from UK Biobank and the GIANT consortium, and from GECCO, CORECT and CCFR consortia.Results: WHI was positively associated with CRC in men (OR per SD: 1.20, 95% CI: 1.03–1.39) and in women (1.15, 1.06–1.24), and similarly for colon and rectal cancer. ABSI was positively associated with colon and rectal cancer in men (1.27, 1.03–1.57; and 1.40, 1.10–1.77, respectively), and with colon cancer in women (1.20, 1.07–1.35). There was little evidence for association between HI and colon or rectal cancer. The BMI-adjusted WHR and HC showed similar associations to WHI and HI, whereas WC showed similar associations to ABSI only in women.Conclusions: This large MR study provides strong evidence for a potential causal positive association of the allometric indices ABSI and WHI with CRC in both sexes, thus establishing the association between abdominal fat and CRC without the limitations of the traditional waist size indices and independently of BMI. Among the BMI-adjusted traditional indices, WHR and HC provided equivalent associations with WHI and HI, while differences were observed between WC and ABSI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Rontogianni, Mar ...
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Bouras, Emmanoui ...
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Aglago, Elom Kou ...
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Freisling, Heinz
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Murphy, Neil
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Cotterchio, Mich ...
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Hampe, Jochen
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Lindblom, Annika
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Pai, Rish K.
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Pharoah, Paul D. ...
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Phipps, Amanda I ...
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van Duijnhoven, ...
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Visvanathan, Kal ...
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van Guelpen, Bet ...
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Li, Christopher ...
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Brenner, Hermann
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Pellatt, Andrew ...
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Ogino, Shuji
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Gunter, Marc J.
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Peters, Ulrike
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Christakoudi, So ...
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Tsilidis, Konsta ...
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