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Spiders use structu...
Spiders use structural conversion of globular amyloidogenic domains to make strong silk fibers
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- Qi, Xingmei (författare)
- The Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China
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- Wang, Han (författare)
- The Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China
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- Wang, Kezhen (författare)
- School of Life Sciences, Anhui Medical University, Anhui, Hefei, China
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- Wang, Yu (författare)
- Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China
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- Leppert, Axel (författare)
- Karolinska Institutet
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- Iashchishyn, Igor (författare)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Zhong, Xueying (författare)
- School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Huddinge, Sweden
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- Zhou, Yizhong (författare)
- Faculty of Food Science and Technology, Suzhou Polytechnic Institute of Agriculture, Suzhou, China
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- Liu, Ruifang (författare)
- The Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China
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- Rising, Anna (författare)
- Karolinska Institutet
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- Landreh, Michael (författare)
- Karolinska Institutet
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- Johansson, Jan (författare)
- Karolinska Institutet
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- Chen, Gefei (författare)
- Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- Wiley-VCH Verlagsgesellschaft, 2024
- 2024
- Engelska.
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Ingår i: Advanced Functional Materials. - : Wiley-VCH Verlagsgesellschaft. - 1616-301X .- 1616-3028. ; 34:23
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Spider silk—an environmentally friendly protein-based material—is widely recognized for its extraordinary mechanical properties. Biomimetic spider silk-like fibers made from recombinant spider silk proteins (spidroins) currently falls short compared to natural silks in terms of mechanical performance. In this study, it is discovered that spiders use structural conversion of molecular enhancers—conserved globular 127-residue spacer domains—to make strong silk fibers. This domain lacks poly-Ala motifs but interestingly contains motifs that are similar to human amyloidogenic motifs, and that it self-assembles into amyloid-like fibrils through a non-nucleation-dependent pathway, likely to avoid the formation of cytotoxic intermediates. Incorporating this spacer domain into a recombinant chimeric spidroin facilitates self-assembly into silk-like fibers, increases fiber molecular homogeneity, and markedly enhances fiber mechanical strength. These findings highlight that spiders employ diverse strategies to produce silk with exceptional mechanical properties. The spacer domain offers a way to enhance the properties of recombinant spider silk-like fibers and other functional materials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- amyloid-like fibril
- mechanical property
- recombinant spider silk
- spacer
- spidroin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Qi, Xingmei
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Wang, Han
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Wang, Kezhen
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Wang, Yu
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Leppert, Axel
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Iashchishyn, Igo ...
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visa fler...
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Zhong, Xueying
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Zhou, Yizhong
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Liu, Ruifang
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Rising, Anna
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Landreh, Michael
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Johansson, Jan
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Chen, Gefei
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Biomaterialveten ...
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- Av lärosätet
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Umeå universitet
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Karolinska Institutet