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Sökning: id:"swepub:oai:DiVA.org:umu-221552" > The acetylase activ...

The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation

Bastidas, Robert J. (författare)
Department of Integrative Immunobiology, Duke University, Durham, United States
Kędzior, Mateusz (författare)
Department of Integrative Immunobiology, Duke University, Durham, United States
Davidson, Robert K. (författare)
Department of Molecular Genetics and Microbiology, Duke University, Duke, United States
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Walsh, Stephen C. (författare)
Department of Molecular Genetics and Microbiology, Duke University, Duke, United States
Dolat, Lee (författare)
Department of Integrative Immunobiology, Duke University, Durham, United States
Sixt, Barbara Susanne (författare)
Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)
Pruneda, Jonathan N. (författare)
Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, United States
Coers, Jörn (författare)
Department of Integrative Immunobiology, Duke University, Durham, United States; Department of Molecular Genetics and Microbiology, Duke University, Duke, United States
Valdivia, Raphael H. (författare)
Department of Integrative Immunobiology, Duke University, Durham, United States; Department of Molecular Genetics and Microbiology, Duke University, Duke, United States
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 (creator_code:org_t)
eLife Sciences Publications Ltd, 2024
2024
Engelska.
Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 12
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Many cellular processes are regulated by ubiquitin-mediated proteasomal degradation. Pathogens can regulate eukaryotic proteolysis through the delivery of proteins with de-ubiquitinating (DUB) activities. The obligate intracellular pathogen Chlamydia trachomatis secretes Cdu1 (ChlaDUB1), a dual deubiquitinase and Lys-acetyltransferase, that promotes Golgi remodeling and survival of infected host cells presumably by regulating the ubiquitination of host and bacterial proteins. Here, we determined that Cdu1's acetylase but not its DUB activity is important to protect Cdu1 from ubiquitin-mediated degradation. We further identified three C. trachomatis proteins on the pathogen-containing vacuole (InaC, IpaM, and CTL0480) that required Cdu1's acetylase activity for protection from degradation and determined that Cdu1 and these Cdu1-protected proteins are required for optimal egress of Chlamydia from host cells. These findings highlight a non-canonical mechanism of pathogen-mediated protection of virulence factors from degradation after their delivery into host cells and the coordinated regulation of secreted effector proteins.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Nyckelord

acetylase
bacterial effectors
bacterial host exit
Chlamydia trachomatis
deubiquitinase
infectious disease
microbiology
ubiquitin

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