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The diagnostic work...
The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex
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- Makhani, Naila (författare)
- Department of Pediatrics, Yale University, LMP 3088, 333 Cedar Street, CT, New Haven, United States; Department of Neurology, Yale University, CT, New Haven, United States
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- Lebrun-Frenay, Christine (författare)
- CRCSEP Neurologie Pasteur 2, CHU de Nice, Université Cote d’Azur, UMR2CA (URRIS), Nice, France
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- Siva, Aksel (författare)
- Neuroimmunology Unit, Neurology Department, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey
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- Shabanova, Veronika (författare)
- Department of Pediatrics, Yale University, LMP 3088, 333 Cedar Street, CT, New Haven, United States
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- Wassmer, Evangeline (författare)
- Neurology Department, Birmingham Children’s Hospital, Aston University, Birmingham, United Kingdom
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- Santoro, Jonathan D. (författare)
- Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, United States; Division of Neurology, Department of Pediatrics, Children’s Hospital of Los Angeles, Los Angeles, United States
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- Narula, Sona (författare)
- Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, United States
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- Brenton, J. Nicholas (författare)
- Department of Neurology, University of Virginia, Charlottesville, United States
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- Mar, Soe (författare)
- Department of Neurology, Washington University School of Medicine, St. Louis, United States
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- Durand-Dubief, Francoise (författare)
- Service de sclérose en plaques, Pathologies de la myéline et Neuro-Inflammation, Hôpital Neurologique, Groupement Hospitalier Est, 59 Bd Pinel, BRON Cedex, France
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- Zephir, Helene (författare)
- Inserm UMR-S 1172 LilNcog, Lille University Hospital FHU Precise, Lille University, Lille, France
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- Mathey, Guillaume (författare)
- Department of Neurology, Nancy University Hospital, Nancy, France
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- Rojas, Juan I. (författare)
- Hospital Universitario de CEMIC, Buenos Aires, Argentina
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- de Seze, Jerome (författare)
- Department of Neurology, Hospital Hautepierre, CHU de Strasbourg and Clinical Investigation Center (CIC) INSERM 1434, Strasbourg, France
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- Tenembaum, Silvia (författare)
- Department of Neurology, National Pediatric Hospital Dr. Juan P Garrahan, Buenos Aires, Argentina
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- Stone, Robert Thompson (författare)
- Department of Neurology, University of Rochester Medical Center, Rochester, United States
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- Casez, Olivier (författare)
- Neurology MS Clinic Grenoble, Grenoble Alpes University Hospital, Grenoble, France; T-RAIG, TIMC-IMAG, Grenoble Alpes University, Grenoble, France
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- Carra-Dallière, Clarisse (författare)
- Neurology MS Clinic, Montpellier University Hospital, Montpellier, France; University of Montpellier (MUSE), Montpellier, France
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- Neuteboom, Rinze F. (författare)
- Department of Neurology, Erasmus MC Rotterdam, Sophia’s Children’s Hospital, Rotterdam, Netherlands
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- Ahsan, Nusrat (författare)
- Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, United States; Division of Neurology, Department of Pediatrics, Children’s Hospital of Los Angeles, Los Angeles, United States
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- Arroyo, Hugo A. (författare)
- Department of Neurology, Hospital de Pediatría SAMIC. Prof. Dr. J.P. Garrahan, Buenos Aires, Argentina
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- Cabre, Philippe (författare)
- Centre Hospitalo Universitaire, Fort-de-France, Martinique
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- Gombolay, Grace (författare)
- Division of Neurology, Department of Pediatrics, Emory University and Children’s Healthcare of Atlanta, GA, Atlanta, United States
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- Inglese, Matilde (författare)
- Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Department of Neuroscience (DINOGMI), University of Genova, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy
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- Louapre, Celine (författare)
- Assistance Publique Hôpitaux de Paris, Inserm, CNRS, Hôpital de la Pitié Salpêtrière, CIC Neurosciences, Sorbonne Université, Paris Brain Institute - ICM, Paris, France
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- Margoni, Monica (författare)
- Department of Neurosciences, Multiple Sclerosis Center of the Veneto Region, University Hospital-School of Medicine, Padua, Italy
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- Palavra, Filipe (författare)
- Center for Child Development - Neuropaediatrics Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
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- Pohl, Daniela (författare)
- Division of Neurology, Children’s Hospital of Eastern Ontario, Ottawa, Canada
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- Reich, Daniel S. (författare)
- Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States
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- Ruet, Aurélie (författare)
- Department of Neurology, CHU Bordeaux, Bordeaux, France; INSERM, Neurocentre Magendie, University of Bordeaux, Bordeaux, France
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- Thouvenot, Eric (författare)
- Department of Neurology, Nîmes University Hospital, Nîmes, France; IGF, University of Montpellier, CNRS, INSERM, Montpellier, France
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- Timby, Niklas (författare)
- Umeå universitet,Pediatrik
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- Tintore, Mar (författare)
- Neurology Department, MS Center of Catalunya Cemcat, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona (UAB), UVIC-Universitat Central de Catalunya, Barcelona, Spain
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- Uygunoglu, Ugur (författare)
- Neuroimmunology Unit, Neurology Department, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey
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- Vargas, Wendy (författare)
- Department of Neurology, Columbia University Medical Center, New York, United States
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- Venkateswaran, Sunita (författare)
- Division of Neurology, Children’s Hospital of Eastern Ontario, Ottawa, Canada
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- Verhelst, Helene (författare)
- Division of Pediatric Neurology, Department of Pediatrics, University Hospital Ghent, Ghent, Belgium
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- Wickstrom, Ronny (författare)
- Neuropaediatric Unit, Department of Women’s and Children’s Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
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- Azevedo, Christina J. (författare)
- Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, United States
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- Kantarci, Orhun (författare)
- Department of Neurology, Mayo Clinic, MN, Rochester, United States
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- Shapiro, Eugene D. (författare)
- Department of Pediatrics, Yale University, LMP 3088, 333 Cedar Street, CT, New Haven, United States
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- Okuda, Darin T. (författare)
- Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, United States
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- Pelletier, Daniel (författare)
- Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, United States
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Journal of Neurology. - : Springer. - 0340-5354 .- 1432-1459.
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Cerebrospinal fluid (CSF) and spinal MRIs are often obtained in children with the radiologically isolated syndrome (RIS) for diagnosis and prognosis. Factors affecting the frequency and timing of these tests are unknown.Objective: To determine whether age or sex were associated with (1) having CSF or spinal MRI obtained or (2) the timing of these tests.Methods: We analyzed children (≤ 18 y) with RIS enrolled in an international longitudinal study. Index scans met 2010/2017 multiple sclerosis (MS) MRI criteria for dissemination in space (DIS). We used Fisher's exact test and multivariable logistic regression (covariates = age, sex, MRI date, MRI indication, 2005 MRI DIS criteria met, and race).Results: We included 103 children with RIS (67% girls, median age = 14.9 y). Children ≥ 12 y were more likely than children < 12 y to have CSF obtained (58% vs. 21%, adjusted odds ratio [AOR] = 4.9, p = 0.03). Pre-2017, girls were more likely than boys to have CSF obtained (n = 70, 79% vs. 52%, AOR = 4.6, p = 0.01), but not more recently (n = 30, 75% vs. 80%, AOR = 0.2, p = 0.1; p = 0.004 for interaction). Spinal MRIs were obtained sooner in children ≥ 12 y (median 11d vs. 159d, p = 0.03).Conclusions: Younger children with RIS may be at continued risk for misdiagnosis and misclassification of MS risk. Consensus guidelines are needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Children
- MRI
- Multiple sclerosis
- Pediatric
- Radiologically isolated syndrome
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Makhani, Naila
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Lebrun-Frenay, C ...
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Siva, Aksel
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Shabanova, Veron ...
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Wassmer, Evangel ...
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Santoro, Jonatha ...
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visa fler...
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Narula, Sona
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Brenton, J. Nich ...
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Mar, Soe
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Durand-Dubief, F ...
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Zephir, Helene
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Mathey, Guillaum ...
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Rojas, Juan I.
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de Seze, Jerome
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Tenembaum, Silvi ...
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Stone, Robert Th ...
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Casez, Olivier
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Carra-Dallière, ...
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Neuteboom, Rinze ...
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Ahsan, Nusrat
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Arroyo, Hugo A.
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Cabre, Philippe
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Gombolay, Grace
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Inglese, Matilde
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Louapre, Celine
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Margoni, Monica
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Palavra, Filipe
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Pohl, Daniela
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Reich, Daniel S.
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Ruet, Aurélie
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Thouvenot, Eric
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Timby, Niklas
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Tintore, Mar
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Uygunoglu, Ugur
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Vargas, Wendy
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Venkateswaran, S ...
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Verhelst, Helene
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Wickstrom, Ronny
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Azevedo, Christi ...
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Kantarci, Orhun
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Shapiro, Eugene ...
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Okuda, Darin T.
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Pelletier, Danie ...
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