Sökning: id:"swepub:oai:DiVA.org:umu-223289" >
Effects and mechani...
Effects and mechanisms of supramaximal High-Intensity Interval Training on extrapulmonary manifestations in people with and without Chronic Obstructive Pulmonary Disease (COPD-HIIT) : study protocol for a multi-centre, randomized controlled trial
-
- Jakobsson, Johan (författare)
- Umeå universitet
-
- Burtin, Chris (författare)
- Hasselt University, Belgium
-
- Hedlund, Mattias (författare)
- Umeå universitet,Avdelningen för fysioterapi
-
visa fler...
-
- Boraxbekk, Carl-Johan, 1980- (författare)
- Bispebjerg Hospital, Institute of Sports Medicine, Copenhagen, Denmark
-
- Vestman, Jonas (författare)
- Umeå universitet,Avdelningen för fysioterapi
-
- Karalija, Nina, 1984- (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
-
- Stål, Per (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
-
- Sandström, Thomas, 1957- (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
-
- Ruttens, David (författare)
- Umeå universitet
-
- Gosker, Harry (författare)
- Universiteit Maastricht School of Nutrition and Translational Research in Metabolism, Maastricht University, Netherlands
-
- De Brandt, Jana, 1991- (författare)
- Umeå universitet,Avdelningen för fysioterapi
-
- Nyberg, Andre, Docent, 1984- (författare)
- Umeå universitet,Avdelningen för fysioterapi
-
visa färre...
-
(creator_code:org_t)
- Engelska.
- Relaterad länk:
-
https://doi.org/10.2...
-
visa fler...
-
https://www.research...
-
https://urn.kb.se/re...
-
https://doi.org/10.2...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Beyond being a pulmonary disease, chronic obstructive pulmonary disease (COPD) presents with extrapulmonary manifestations including reduced cognitive, cardiovascular, and muscle function. While exercise training is the cornerstone in the non-pharmacological treatment of COPD, there is a need for new exercise training methods due to suboptimal adaptations when following traditional exercise guidelines, often applying moderate-intensity continuous training (MICT). In people with COPD, short-duration high-intensity interval training (HIIT) holds the potential to induce a more optimal stimulus for training adaptations while circumventing the ventilatory burden often associated with MICT in people with COPD. We aim to determine the effects of supramaximal HIIT and MICT on extrapulmonary manifestations in people with COPD compared to matched healthy controls.Methods: COPD-HIIT is a prospective, multi-centre, randomised, controlled trial with blinded assessors and data analysts, employing a parallel-group trial. In Phase 1, we will investigate the effects and mechanisms of a 12-week intervention of supramaximal HIIT compared to MICT in people with COPD (n = 92) and matched healthy controls (n = 70). Participants will perform watt-based cycling 2–3 times weekly. In Phase 2, we will determine how exercise training and inflammation impact the trajectories of neurodegeneration, in people with COPD, over 24 months. In addition to the 92 participants with COPD performing HIIT or MICT, a usual care group (n = 46) is included in phase 2. In both phases, the primary outcomes are change from baseline in cognitive function, cardiorespiratory fitness, and muscle power. Key secondary outcomes include change from baseline exercise tolerance, brain structure and function measured by MRI, neuroinflammation measured by PET/CT, systemic inflammation, and intramuscular adaptations. Feasibility of the interventions will be comprehensively investigated.Discussion: The COPD-HIIT trial will determine the effects of supramaximal HIIT compared to MICT in people with COPD and healthy controls. We will provide evidence for a novel exercise modality that might overcome the barriers associated with MICT in people with COPD. We will also shed light on the impact of exercise at different intensities to reduce neurodegeneration. The goal of the COPD-HIIT trial is to improve the treatment of extrapulmonary manifestations of the disease.Trial registration: Clinicaltrials.gov: NCT06068322. Prospectively registered on 2023-09-28.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- High-Intensity Interval Training
- Pulmonary Disease
- Chronic Obstructive
- Randomized Controlled Trial
- Aerobic Exercise
- Cognitive Aspects
- Neurodegeneration
- Systemic inflammation
- Skeletal Muscle
- Sports Medicine
- idrottsmedicin
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)
- Av författaren/redakt...
-
Jakobsson, Johan
-
Burtin, Chris
-
Hedlund, Mattias
-
Boraxbekk, Carl- ...
-
Vestman, Jonas
-
Karalija, Nina, ...
-
visa fler...
-
Stål, Per
-
Sandström, Thoma ...
-
Ruttens, David
-
Gosker, Harry
-
De Brandt, Jana, ...
-
Nyberg, Andre, D ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Av lärosätet
-
Umeå universitet