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TCF7L2 polymorphism...
TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden
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- Mayans, Sofia, 1976- (författare)
- Umeå universitet,Medicinsk och klinisk genetik,Sofia Mayans
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- Lackovic, Kurt (författare)
- Umeå universitet,Medicinsk och klinisk genetik
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- Lindgren, Petter (författare)
- Umeå universitet,Medicinsk och klinisk genetik
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- Ruikka, Karin (författare)
- Department of Medicine, Sunderby Hospital, Luleå
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- Ågren, Åsa (författare)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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- Eliasson, Mats (författare)
- Umeå universitet,Medicin,Department of Medicine, Sunderby Hospital, Luleå
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- Holmberg, Dan (författare)
- Umeå universitet,Medicinsk och klinisk genetik,Umeå centrum för molekylär medicin (UCMM)
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(creator_code:org_t)
- 2007-01-24
- 2007
- Engelska.
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Ingår i: European Journal of Human Genetics. - : Nature Publishing Group. - 1018-4813 .- 1476-5438. ; 15:3, s. 342-346
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A recent study found association of one microsatellite and five single nucleotide polymorphisms (SNPs) in intron 3 of the TCF7L2 gene with type 2 diabetes (T2D) in the Icelandic, Danish and American populations. The aim of the present study was to investigate if those SNPs were associated to T2D in two (family- and population-based) cohorts from northern Sweden. We genotyped four of the associated SNPs in a case-control cohort consisting of 872 T2D cases and 857 controls matched with respect to age, sex and geographical origin and in a sample of 59 extended families (148 affected and 83 unaffected individuals). Here, we report replication of association between T2D and three SNPs in the case-control (rs7901695, P=0.003; rs7901346, P=0.00002; and rs12255372, P=0.000004) and two SNPs in the family-based (rs7901695, P=0.01 and rs7901346, P=0.04) samples from northern Sweden. This replication strengthens the evidence for involvement of TCF7L2 in T2D.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- association
- diabetes
- polymorphism
- TCF7L2
- Case-Control Studies
- Diabetes Mellitus; Type 2/*genetics
- Family
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Polymorphism; Single Nucleotide
- Sweden
- TCF Transcription Factors/*genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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